VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia
Aim. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia. Material and Method. One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing a...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2016/6074275 |
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| author | Ioana Cristina Rotar Diana Elena Dumitras Radu Anghel Popp Felicia Maria Petrisor Paul Cotutiu Florin Stamatian Daniel Muresan |
| author_facet | Ioana Cristina Rotar Diana Elena Dumitras Radu Anghel Popp Felicia Maria Petrisor Paul Cotutiu Florin Stamatian Daniel Muresan |
| author_sort | Ioana Cristina Rotar |
| collection | DOAJ |
| description | Aim. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia. Material and Method. One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing and cytology). For each patient a single visit was scheduled when colposcopy was performed. From cervical specimen, cytology and HPV testing were performed and from peripheral blood VEGF +936 genotyping was determined. For statistical analysis purposes OR and chi-square were used at a level of significance of <0.05. Results. No link has been found in the detection of CT genotype in cases versus controls, OR = 0.8295, [0.42, 1.62]. An inverse correlation has been found between T allele and HSIL, OR = 0.2121, [0.0473, 0.9517], p=0.0866. Conclusion. No link has been found between VEGF +936 C/T and cervical intraepithelial neoplasia. |
| format | Article |
| id | doaj-art-ec7501666dd947b7b425b0b9a3279312 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-ec7501666dd947b7b425b0b9a32793122025-02-03T05:45:32ZengWileyAnalytical Cellular Pathology2210-71772210-71852016-01-01201610.1155/2016/60742756074275VEGF +936 C/T Genetic Polymorphism in Patients with Cervical DysplasiaIoana Cristina Rotar0Diana Elena Dumitras1Radu Anghel Popp2Felicia Maria Petrisor3Paul Cotutiu4Florin Stamatian5Daniel Muresan61st Clinic of Obstetrics and Gynecology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Clinicilor 3-5, 400006 Cluj-Napoca, RomaniaDepartment of Economic Sciences, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Manastur 3-5, 400372 Cluj-Napoca, RomaniaDepartment of Molecular Sciences, University of Medicine and Pharmacy “Iuliu Hatieganu”, Clinicilor 3-5, 400006 Cluj-Napoca, RomaniaDepartment of Molecular Sciences, University of Medicine and Pharmacy “Iuliu Hatieganu”, Clinicilor 3-5, 400006 Cluj-Napoca, Romania1st Clinic of Obstetrics and Gynecology, Emergency County Hospital, Cluj-Napoca, Romania1st Clinic of Obstetrics and Gynecology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Clinicilor 3-5, 400006 Cluj-Napoca, Romania1st Clinic of Obstetrics and Gynecology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Clinicilor 3-5, 400006 Cluj-Napoca, RomaniaAim. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia. Material and Method. One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing and cytology). For each patient a single visit was scheduled when colposcopy was performed. From cervical specimen, cytology and HPV testing were performed and from peripheral blood VEGF +936 genotyping was determined. For statistical analysis purposes OR and chi-square were used at a level of significance of <0.05. Results. No link has been found in the detection of CT genotype in cases versus controls, OR = 0.8295, [0.42, 1.62]. An inverse correlation has been found between T allele and HSIL, OR = 0.2121, [0.0473, 0.9517], p=0.0866. Conclusion. No link has been found between VEGF +936 C/T and cervical intraepithelial neoplasia.http://dx.doi.org/10.1155/2016/6074275 |
| spellingShingle | Ioana Cristina Rotar Diana Elena Dumitras Radu Anghel Popp Felicia Maria Petrisor Paul Cotutiu Florin Stamatian Daniel Muresan VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia Analytical Cellular Pathology |
| title | VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia |
| title_full | VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia |
| title_fullStr | VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia |
| title_full_unstemmed | VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia |
| title_short | VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia |
| title_sort | vegf 936 c t genetic polymorphism in patients with cervical dysplasia |
| url | http://dx.doi.org/10.1155/2016/6074275 |
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