Safety assessment of preventive pressurized intraperitoneal aerosol chemotherapy in combined treatment of gastric cancer: preliminary results
Purpose of the study. Preventive pressurised intraperitoneal aerosol chemotherapy (PIPAC) safety assessment in the combined treatment of gastric cancer (GC).Patients and methods. The study included 48 patients with morphologically confirmed resectable GC and cardio esophageal transition, having at l...
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QUASAR, LLC
2024-03-01
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| Series: | Исследования и практика в медицине |
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| Online Access: | https://www.rpmj.ru/rpmj/article/view/980 |
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| author | N. Ya. Muratova I. V. Kolobaev D. D. Kudryavtsev E. I. Smolenov A. B. Ryabov V. M. Khomyakov L. O. Petrov S. A. Ivanov A. D. Kaprin |
| author_facet | N. Ya. Muratova I. V. Kolobaev D. D. Kudryavtsev E. I. Smolenov A. B. Ryabov V. M. Khomyakov L. O. Petrov S. A. Ivanov A. D. Kaprin |
| author_sort | N. Ya. Muratova |
| collection | DOAJ |
| description | Purpose of the study. Preventive pressurised intraperitoneal aerosol chemotherapy (PIPAC) safety assessment in the combined treatment of gastric cancer (GC).Patients and methods. The study included 48 patients with morphologically confirmed resectable GC and cardio esophageal transition, having at least one criterion that is a predictor of the development of peritoneal carcinomatosis, e. g. tumor spread to the serous layer (≥ T4a), diffuse tumor type, affected regional lymph nodes, large tumor, young age (up to 45 years), subtotally and totally affected stomach. 36 out of those patients received treatment according to the protocol. All patients received 4 cycles of neoadjuvant chemotherapy according to the FLOT scheme, radical surgical treatment in combination with a PIPAC session, 4 cycles of adjuvant chemotherapy according to the FLOT scheme. The safety assessment was carried out according to the classification of surgical complications according to Clavien-D indo and the international scale for toxicity scaling NCI–CTCAE v5.0.Results. Postoperative complications were diagnosed in 25 %, >III grade complications were revealed in 11 % of cases according to the Clavien-D indo classification. The postoperative mortality rate was 0 %.Conclusion. Preventive PIPAC of locally advanced GC and CET in combined treatment is a reproducible and safe method, which is characterized by the absence of an increase in the number of postoperative complications and mortality rate. |
| format | Article |
| id | doaj-art-ec72e5be86814c4ea235661961626a23 |
| institution | Kabale University |
| issn | 2410-1893 |
| language | Russian |
| publishDate | 2024-03-01 |
| publisher | QUASAR, LLC |
| record_format | Article |
| series | Исследования и практика в медицине |
| spelling | doaj-art-ec72e5be86814c4ea235661961626a232025-02-03T00:57:40ZrusQUASAR, LLCИсследования и практика в медицине2410-18932024-03-0111181810.17709/2410-1893-2024-11-1-1529Safety assessment of preventive pressurized intraperitoneal aerosol chemotherapy in combined treatment of gastric cancer: preliminary resultsN. Ya. Muratova0I. V. Kolobaev1D. D. Kudryavtsev2E. I. Smolenov3A. B. Ryabov4V. M. Khomyakov5L. O. Petrov6S. A. Ivanov7A. D. Kaprin8A. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation <p> Obninsk, Russian FederationA. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation <p> Obninsk, Russian FederationA. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation <p> Obninsk, Russian FederationA. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation <p> Obninsk, Russian FederationP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation <p> Moscow, Russian FederationP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation <p> Moscow, Russian FederationA. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation <p> Obninsk, Russian FederationA. Tsyb Medical Radiological Research Centre – Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation <p> Obninsk, Russian Federation <p> Peoples' Friendship University of Russia <p> Moscow, Russian FederationP. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation<p> Moscow, Russian Federation <p> National Medical Research Radiological Centre, Ministry of Health of the Russian Federation<p> Obninsk, Russian Federation <p> Peoples' Friendship University of Russia<p> Moscow, Russian FederationPurpose of the study. Preventive pressurised intraperitoneal aerosol chemotherapy (PIPAC) safety assessment in the combined treatment of gastric cancer (GC).Patients and methods. The study included 48 patients with morphologically confirmed resectable GC and cardio esophageal transition, having at least one criterion that is a predictor of the development of peritoneal carcinomatosis, e. g. tumor spread to the serous layer (≥ T4a), diffuse tumor type, affected regional lymph nodes, large tumor, young age (up to 45 years), subtotally and totally affected stomach. 36 out of those patients received treatment according to the protocol. All patients received 4 cycles of neoadjuvant chemotherapy according to the FLOT scheme, radical surgical treatment in combination with a PIPAC session, 4 cycles of adjuvant chemotherapy according to the FLOT scheme. The safety assessment was carried out according to the classification of surgical complications according to Clavien-D indo and the international scale for toxicity scaling NCI–CTCAE v5.0.Results. Postoperative complications were diagnosed in 25 %, >III grade complications were revealed in 11 % of cases according to the Clavien-D indo classification. The postoperative mortality rate was 0 %.Conclusion. Preventive PIPAC of locally advanced GC and CET in combined treatment is a reproducible and safe method, which is characterized by the absence of an increase in the number of postoperative complications and mortality rate.https://www.rpmj.ru/rpmj/article/view/980pressurized intraperitoneal aerosol chemotherapygastric cancercombination treatment |
| spellingShingle | N. Ya. Muratova I. V. Kolobaev D. D. Kudryavtsev E. I. Smolenov A. B. Ryabov V. M. Khomyakov L. O. Petrov S. A. Ivanov A. D. Kaprin Safety assessment of preventive pressurized intraperitoneal aerosol chemotherapy in combined treatment of gastric cancer: preliminary results Исследования и практика в медицине pressurized intraperitoneal aerosol chemotherapy gastric cancer combination treatment |
| title | Safety assessment of preventive pressurized intraperitoneal aerosol chemotherapy in combined treatment of gastric cancer: preliminary results |
| title_full | Safety assessment of preventive pressurized intraperitoneal aerosol chemotherapy in combined treatment of gastric cancer: preliminary results |
| title_fullStr | Safety assessment of preventive pressurized intraperitoneal aerosol chemotherapy in combined treatment of gastric cancer: preliminary results |
| title_full_unstemmed | Safety assessment of preventive pressurized intraperitoneal aerosol chemotherapy in combined treatment of gastric cancer: preliminary results |
| title_short | Safety assessment of preventive pressurized intraperitoneal aerosol chemotherapy in combined treatment of gastric cancer: preliminary results |
| title_sort | safety assessment of preventive pressurized intraperitoneal aerosol chemotherapy in combined treatment of gastric cancer preliminary results |
| topic | pressurized intraperitoneal aerosol chemotherapy gastric cancer combination treatment |
| url | https://www.rpmj.ru/rpmj/article/view/980 |
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