Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by motor and nonmotor signs and symptoms. To date, many studies of PD have focused on its cardinal motor symptoms. To study the nonmotor signs of early PD, we investigated the reactions solicited by heat pain stimuli i...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2015/273019 |
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| author | Ying Tan Juan Tan Cheng Luo Wenjuan Cui Hui He Yi Bin Jiayan Deng Rui Tan Wenrong Tan Tao Liu Nanlin Zeng Ruhui Xiao Dezhong Yao Xiaoming Wang |
| author_facet | Ying Tan Juan Tan Cheng Luo Wenjuan Cui Hui He Yi Bin Jiayan Deng Rui Tan Wenrong Tan Tao Liu Nanlin Zeng Ruhui Xiao Dezhong Yao Xiaoming Wang |
| author_sort | Ying Tan |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by motor and nonmotor signs and symptoms. To date, many studies of PD have focused on its cardinal motor symptoms. To study the nonmotor signs of early PD, we investigated the reactions solicited by heat pain stimuli in early untreated PD patients without pain using fMRI. The activation patterns of contact heat stimuli (51°C) were assessed in 14 patients and 17 age- and sex-matched healthy controls. Patients with PD showed significant decreases in activation of the superior temporal gyrus (STG) and insula compared with controls. In addition, a significant relationship between activation of the insula and STG and the pain scores was observed in healthy controls but not in PD. This study provided further support that the insula and STG are important parts of the somatosensory circuitry recruited during the period of pain. The hypoactivity of the STG and insula in PD implied that functions including affective, cognitive, and sensory-discriminative processes, which are associated with the insula and STG, were disturbed. This finding supports the view that leaving early PD untreated could be tied directly to central nervous system dysfunction. |
| format | Article |
| id | doaj-art-ec6d027ea5ca47b882dbf6195b5fb2f0 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-ec6d027ea5ca47b882dbf6195b5fb2f02025-02-03T01:31:38ZengWileyParkinson's Disease2090-80832042-00802015-01-01201510.1155/2015/273019273019Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI StudyYing Tan0Juan Tan1Cheng Luo2Wenjuan Cui3Hui He4Yi Bin5Jiayan Deng6Rui Tan7Wenrong Tan8Tao Liu9Nanlin Zeng10Ruhui Xiao11Dezhong Yao12Xiaoming Wang13The Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, ChinaNeurology Department, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong 637000, ChinaThe Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, ChinaNeurology Department, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong 637000, ChinaThe Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, ChinaThe Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, ChinaThe Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, ChinaSchool of Life and Science Engineering, Southwest Jiaotong University, Chengdu 610031, ChinaSchool of Computer Science and Technology, Southwest University for Nationalities, Chengdu 610041, ChinaSchool of Computer Science and Technology, Southwest University for Nationalities, Chengdu 610041, ChinaNeurology Department, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong 637000, ChinaNeurology Department, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong 637000, ChinaThe Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, ChinaNeurology Department, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong 637000, ChinaParkinson’s disease (PD) is a progressive neurodegenerative disease characterized by motor and nonmotor signs and symptoms. To date, many studies of PD have focused on its cardinal motor symptoms. To study the nonmotor signs of early PD, we investigated the reactions solicited by heat pain stimuli in early untreated PD patients without pain using fMRI. The activation patterns of contact heat stimuli (51°C) were assessed in 14 patients and 17 age- and sex-matched healthy controls. Patients with PD showed significant decreases in activation of the superior temporal gyrus (STG) and insula compared with controls. In addition, a significant relationship between activation of the insula and STG and the pain scores was observed in healthy controls but not in PD. This study provided further support that the insula and STG are important parts of the somatosensory circuitry recruited during the period of pain. The hypoactivity of the STG and insula in PD implied that functions including affective, cognitive, and sensory-discriminative processes, which are associated with the insula and STG, were disturbed. This finding supports the view that leaving early PD untreated could be tied directly to central nervous system dysfunction.http://dx.doi.org/10.1155/2015/273019 |
| spellingShingle | Ying Tan Juan Tan Cheng Luo Wenjuan Cui Hui He Yi Bin Jiayan Deng Rui Tan Wenrong Tan Tao Liu Nanlin Zeng Ruhui Xiao Dezhong Yao Xiaoming Wang Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study Parkinson's Disease |
| title | Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study |
| title_full | Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study |
| title_fullStr | Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study |
| title_full_unstemmed | Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study |
| title_short | Altered Brain Activation in Early Drug-Naive Parkinson’s Disease during Heat Pain Stimuli: An fMRI Study |
| title_sort | altered brain activation in early drug naive parkinson s disease during heat pain stimuli an fmri study |
| url | http://dx.doi.org/10.1155/2015/273019 |
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