Translocation of Clostridium difficile Toxin B across Polarized Caco-2 Cell Monolayers Is Enhanced by Toxin A
Clostridium difficile is the etiological agent of antibiotic-associated diarrhea; the most common form of nosocomial infectious diarrhea. The basis for the shock-like systemic symptoms observed in severe cases of this infection are not known. It is hypothesized that the invasion of C difficile toxin...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2004/292580 |
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| _version_ | 1832560566214852608 |
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| author | Tim Du Michelle J Alfa |
| author_facet | Tim Du Michelle J Alfa |
| author_sort | Tim Du |
| collection | DOAJ |
| description | Clostridium difficile is the etiological agent of antibiotic-associated diarrhea; the most common form of nosocomial infectious diarrhea. The basis for the shock-like systemic symptoms observed in severe cases of this infection are not known. It is hypothesized that the invasion of C difficile toxins A and/or B from the gut mucosa may contribute to these symptoms. |
| format | Article |
| id | doaj-art-ec6896a3be064e0f9ad180f011f9d6c3 |
| institution | Kabale University |
| issn | 1180-2332 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-ec6896a3be064e0f9ad180f011f9d6c32025-02-03T01:27:15ZengWileyCanadian Journal of Infectious Diseases1180-23322004-01-01152838810.1155/2004/292580Translocation of Clostridium difficile Toxin B across Polarized Caco-2 Cell Monolayers Is Enhanced by Toxin ATim Du0Michelle J Alfa1Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, CanadaSt Boniface General Hospital, Winnipeg, Manitoba, CanadaClostridium difficile is the etiological agent of antibiotic-associated diarrhea; the most common form of nosocomial infectious diarrhea. The basis for the shock-like systemic symptoms observed in severe cases of this infection are not known. It is hypothesized that the invasion of C difficile toxins A and/or B from the gut mucosa may contribute to these symptoms.http://dx.doi.org/10.1155/2004/292580 |
| spellingShingle | Tim Du Michelle J Alfa Translocation of Clostridium difficile Toxin B across Polarized Caco-2 Cell Monolayers Is Enhanced by Toxin A Canadian Journal of Infectious Diseases |
| title | Translocation of Clostridium difficile Toxin B across Polarized Caco-2 Cell Monolayers Is Enhanced by Toxin A |
| title_full | Translocation of Clostridium difficile Toxin B across Polarized Caco-2 Cell Monolayers Is Enhanced by Toxin A |
| title_fullStr | Translocation of Clostridium difficile Toxin B across Polarized Caco-2 Cell Monolayers Is Enhanced by Toxin A |
| title_full_unstemmed | Translocation of Clostridium difficile Toxin B across Polarized Caco-2 Cell Monolayers Is Enhanced by Toxin A |
| title_short | Translocation of Clostridium difficile Toxin B across Polarized Caco-2 Cell Monolayers Is Enhanced by Toxin A |
| title_sort | translocation of clostridium difficile toxin b across polarized caco 2 cell monolayers is enhanced by toxin a |
| url | http://dx.doi.org/10.1155/2004/292580 |
| work_keys_str_mv | AT timdu translocationofclostridiumdifficiletoxinbacrosspolarizedcaco2cellmonolayersisenhancedbytoxina AT michellejalfa translocationofclostridiumdifficiletoxinbacrosspolarizedcaco2cellmonolayersisenhancedbytoxina |