Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Product Characterization
Ultrafine nanoparticles, less than 10 nm in mean diameter, of the FDA approved copolymer methyl methacrylate- (MMA-) co-methacrylic acid (MAA), 2/1 (mol/mol), were prepared. The method used for the preparation of these particles stabilized in a latex containing around 11% solids includes the dosing...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2016/7674620 |
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| author | Henned Saade María de Lourdes Guillén Judith Cabello Romero Jesús Cepeda Anna Ilyna Salvador Fernández Francisco Javier Enríquez-Medrano Raúl Guillermo López |
| author_facet | Henned Saade María de Lourdes Guillén Judith Cabello Romero Jesús Cepeda Anna Ilyna Salvador Fernández Francisco Javier Enríquez-Medrano Raúl Guillermo López |
| author_sort | Henned Saade |
| collection | DOAJ |
| description | Ultrafine nanoparticles, less than 10 nm in mean diameter, of the FDA approved copolymer methyl methacrylate- (MMA-) co-methacrylic acid (MAA), 2/1 (mol/mol), were prepared. The method used for the preparation of these particles stabilized in a latex containing around 11% solids includes the dosing of the monomers mixture on a micellar solution preserving monomer starved conditions. It is thought that the operation at these conditions combined with the hydrophilicity of MMA and MAA units favors the formation of ultrafine particles; the propagation reaction carried out within so small compartments renders copolymer chains rich in syndiotactic units very likely as consequence of the restricted movements of the end propagation of the chains. Because of their biocompatibility and biodegradability as well as their extremely small size these nanoparticles could be used as vehicles for improved drug delivery in the treatment of chronic-degenerative diseases. |
| format | Article |
| id | doaj-art-ec5847ad1e4b4389865ca605c4b85364 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-ec5847ad1e4b4389865ca605c4b853642025-02-03T01:01:51ZengWileyInternational Journal of Polymer Science1687-94221687-94302016-01-01201610.1155/2016/76746207674620Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Product CharacterizationHenned Saade0María de Lourdes Guillén1Judith Cabello Romero2Jesús Cepeda3Anna Ilyna4Salvador Fernández5Francisco Javier Enríquez-Medrano6Raúl Guillermo López7Departamentos de Procesos de Polimerización y Síntesis de Polímeros, Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna No. 140, 25294 Saltillo, COAH, MexicoDepartamentos de Procesos de Polimerización y Síntesis de Polímeros, Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna No. 140, 25294 Saltillo, COAH, MexicoDepartamentos de Procesos de Polimerización y Síntesis de Polímeros, Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna No. 140, 25294 Saltillo, COAH, MexicoDepartamentos de Procesos de Polimerización y Síntesis de Polímeros, Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna No. 140, 25294 Saltillo, COAH, MexicoDepartamento de Nanobiociencias, Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila, Blvd. V. Carranza y José Cárdenas Valdés S/N, 25280 Saltillo, COAH, MexicoDepartamentos de Procesos de Polimerización y Síntesis de Polímeros, Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna No. 140, 25294 Saltillo, COAH, MexicoDepartamentos de Procesos de Polimerización y Síntesis de Polímeros, Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna No. 140, 25294 Saltillo, COAH, MexicoDepartamentos de Procesos de Polimerización y Síntesis de Polímeros, Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna No. 140, 25294 Saltillo, COAH, MexicoUltrafine nanoparticles, less than 10 nm in mean diameter, of the FDA approved copolymer methyl methacrylate- (MMA-) co-methacrylic acid (MAA), 2/1 (mol/mol), were prepared. The method used for the preparation of these particles stabilized in a latex containing around 11% solids includes the dosing of the monomers mixture on a micellar solution preserving monomer starved conditions. It is thought that the operation at these conditions combined with the hydrophilicity of MMA and MAA units favors the formation of ultrafine particles; the propagation reaction carried out within so small compartments renders copolymer chains rich in syndiotactic units very likely as consequence of the restricted movements of the end propagation of the chains. Because of their biocompatibility and biodegradability as well as their extremely small size these nanoparticles could be used as vehicles for improved drug delivery in the treatment of chronic-degenerative diseases.http://dx.doi.org/10.1155/2016/7674620 |
| spellingShingle | Henned Saade María de Lourdes Guillén Judith Cabello Romero Jesús Cepeda Anna Ilyna Salvador Fernández Francisco Javier Enríquez-Medrano Raúl Guillermo López Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Product Characterization International Journal of Polymer Science |
| title | Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Product Characterization |
| title_full | Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Product Characterization |
| title_fullStr | Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Product Characterization |
| title_full_unstemmed | Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Product Characterization |
| title_short | Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Product Characterization |
| title_sort | biocompatible and biodegradable ultrafine nanoparticles of poly methyl methacrylate co methacrylic acid prepared via semicontinuous heterophase polymerization kinetics and product characterization |
| url | http://dx.doi.org/10.1155/2016/7674620 |
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