The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis
Individuals with cystic fibrosis (CF) present with severe airway destruction and extensive bronchiectasis. It has been assumed that these structural airway changes have occurred secondary to infection and inflammation, but recent studies suggest that glycosaminoglycan (GAG) remodelling may be an imp...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2011.81 |
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| author | Emer P. Reeves David A. Bergin Michelle A. Murray Noel G. McElvaney |
| author_facet | Emer P. Reeves David A. Bergin Michelle A. Murray Noel G. McElvaney |
| author_sort | Emer P. Reeves |
| collection | DOAJ |
| description | Individuals with cystic fibrosis (CF) present with severe airway destruction and extensive bronchiectasis. It has been assumed that these structural airway changes have occurred secondary to infection and inflammation, but recent studies suggest that glycosaminoglycan (GAG) remodelling may be an important independent parallel process. Evidence is accumulating that not only the concentration, but also sulphation of GAGs is markedly increased in CF bronchial cells and tissues. Increased expression of GAGs and, in particular, heparan sulphate, has been linked to a sustained inflammatory response and neutrophil recruitment to the CF airways. This present review discusses the biological role of GAGs in the lung, as well as their involvement in CF respiratory disease, and their potential as therapeutic targets. |
| format | Article |
| id | doaj-art-ec525f7284384e4abbcc98cd2e431cc1 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-ec525f7284384e4abbcc98cd2e431cc12025-02-03T06:01:16ZengWileyThe Scientific World Journal1537-744X2011-01-011195997110.1100/tsw.2011.81The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic FibrosisEmer P. Reeves0David A. Bergin1Michelle A. Murray2Noel G. McElvaney3Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandIndividuals with cystic fibrosis (CF) present with severe airway destruction and extensive bronchiectasis. It has been assumed that these structural airway changes have occurred secondary to infection and inflammation, but recent studies suggest that glycosaminoglycan (GAG) remodelling may be an important independent parallel process. Evidence is accumulating that not only the concentration, but also sulphation of GAGs is markedly increased in CF bronchial cells and tissues. Increased expression of GAGs and, in particular, heparan sulphate, has been linked to a sustained inflammatory response and neutrophil recruitment to the CF airways. This present review discusses the biological role of GAGs in the lung, as well as their involvement in CF respiratory disease, and their potential as therapeutic targets.http://dx.doi.org/10.1100/tsw.2011.81 |
| spellingShingle | Emer P. Reeves David A. Bergin Michelle A. Murray Noel G. McElvaney The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis The Scientific World Journal |
| title | The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis |
| title_full | The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis |
| title_fullStr | The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis |
| title_full_unstemmed | The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis |
| title_short | The Involvement of Glycosaminoglycans in Airway Disease Associated with Cystic Fibrosis |
| title_sort | involvement of glycosaminoglycans in airway disease associated with cystic fibrosis |
| url | http://dx.doi.org/10.1100/tsw.2011.81 |
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