The Effect of the Thai Herbal Suksaiyad Formula on Platelet Aggregation in Healthy Volunteers: A Quasi-experimental, Single-dose Study
Objective: To investigate the effects of the Thai Herbal Suksaiyad formula (SSF) on platelet aggregation in healthy volunteers. Material and Methods: In a quasi-experimental study, thirty healthy volunteers received a single dose of 2,000 mg SSF. Blood samples were taken at 0, 3, 6, and 24 hours...
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Faculty of Medicine Siriraj Hospital
2025-02-01
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| Series: | Siriraj Medical Journal |
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| Online Access: | https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/271976 |
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| author | Titchaphorn Palo Nalinthika Nathananwanit Pravit Akarasereenont Suksalin Booranasubkajorn |
| author_facet | Titchaphorn Palo Nalinthika Nathananwanit Pravit Akarasereenont Suksalin Booranasubkajorn |
| author_sort | Titchaphorn Palo |
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Objective: To investigate the effects of the Thai Herbal Suksaiyad formula (SSF) on platelet aggregation in healthy volunteers.
Material and Methods: In a quasi-experimental study, thirty healthy volunteers received a single dose of 2,000 mg SSF. Blood samples were taken at 0, 3, 6, and 24 hours after SSF administration for platelet aggregation analysis using aggregometry. Platelets were induced with epinephrine, adenosine diphosphate, and collagen.
Results: SSF significantly decreased platelet aggregation at 3 and 6 hours post-administration. Sub-analysis revealed no significant differences between males and females. SSF significantly decreased platelet aggregation in normal and hyperaggregation groups but had no effect on the disaggregation group. The effect of SSF was short-lived, reverting to pre-dose values after 24 hours for all agonists. Adverse events included flatulence (1 participant) and diarrhea (1 participant).
Conclusion: Caution is advised when using SSF in patients with blood disorders. Potential herb-drug interactions between SSF and drugs that impact platelet aggregation, such as aspirin, should be closely monitored. These interactions could result in fluctuations that may enhance or diminish the effectiveness of concurrent antiplatelet therapies, potentially increasing the risk of bleeding or decreasing therapeutic outcomes.
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| format | Article |
| id | doaj-art-ec4899b46cf94f3fbe887b60d461b54e |
| institution | Kabale University |
| issn | 2228-8082 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Faculty of Medicine Siriraj Hospital |
| record_format | Article |
| series | Siriraj Medical Journal |
| spelling | doaj-art-ec4899b46cf94f3fbe887b60d461b54e2025-02-03T07:37:09ZengFaculty of Medicine Siriraj HospitalSiriraj Medical Journal2228-80822025-02-0177210.33192/smj.v77i2.271976The Effect of the Thai Herbal Suksaiyad Formula on Platelet Aggregation in Healthy Volunteers: A Quasi-experimental, Single-dose StudyTitchaphorn Palo0Nalinthika Nathananwanit1Pravit Akarasereenont2Suksalin Booranasubkajorn3Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandCenter of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandCenter of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Objective: To investigate the effects of the Thai Herbal Suksaiyad formula (SSF) on platelet aggregation in healthy volunteers. Material and Methods: In a quasi-experimental study, thirty healthy volunteers received a single dose of 2,000 mg SSF. Blood samples were taken at 0, 3, 6, and 24 hours after SSF administration for platelet aggregation analysis using aggregometry. Platelets were induced with epinephrine, adenosine diphosphate, and collagen. Results: SSF significantly decreased platelet aggregation at 3 and 6 hours post-administration. Sub-analysis revealed no significant differences between males and females. SSF significantly decreased platelet aggregation in normal and hyperaggregation groups but had no effect on the disaggregation group. The effect of SSF was short-lived, reverting to pre-dose values after 24 hours for all agonists. Adverse events included flatulence (1 participant) and diarrhea (1 participant). Conclusion: Caution is advised when using SSF in patients with blood disorders. Potential herb-drug interactions between SSF and drugs that impact platelet aggregation, such as aspirin, should be closely monitored. These interactions could result in fluctuations that may enhance or diminish the effectiveness of concurrent antiplatelet therapies, potentially increasing the risk of bleeding or decreasing therapeutic outcomes. https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/271976Thai Herbal Suksaiyad formulaHerbal medicinePlatelet aggregationThai traditional medicine |
| spellingShingle | Titchaphorn Palo Nalinthika Nathananwanit Pravit Akarasereenont Suksalin Booranasubkajorn The Effect of the Thai Herbal Suksaiyad Formula on Platelet Aggregation in Healthy Volunteers: A Quasi-experimental, Single-dose Study Siriraj Medical Journal Thai Herbal Suksaiyad formula Herbal medicine Platelet aggregation Thai traditional medicine |
| title | The Effect of the Thai Herbal Suksaiyad Formula on Platelet Aggregation in Healthy Volunteers: A Quasi-experimental, Single-dose Study |
| title_full | The Effect of the Thai Herbal Suksaiyad Formula on Platelet Aggregation in Healthy Volunteers: A Quasi-experimental, Single-dose Study |
| title_fullStr | The Effect of the Thai Herbal Suksaiyad Formula on Platelet Aggregation in Healthy Volunteers: A Quasi-experimental, Single-dose Study |
| title_full_unstemmed | The Effect of the Thai Herbal Suksaiyad Formula on Platelet Aggregation in Healthy Volunteers: A Quasi-experimental, Single-dose Study |
| title_short | The Effect of the Thai Herbal Suksaiyad Formula on Platelet Aggregation in Healthy Volunteers: A Quasi-experimental, Single-dose Study |
| title_sort | effect of the thai herbal suksaiyad formula on platelet aggregation in healthy volunteers a quasi experimental single dose study |
| topic | Thai Herbal Suksaiyad formula Herbal medicine Platelet aggregation Thai traditional medicine |
| url | https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/271976 |
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