Clinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysis
Abstract To evaluate the clinical utility of PCT, CRP, IL-6, NLR, and TyG index in improving the early diagnosis and severity assessment of acute pancreatitis (AP). This retrospective study included 137 AP patients and 30 healthy controls from Hunan Provincial People’s Hospital (January 2021–Septemb...
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2025-01-01
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| author | Xu Xinyu Zhou Jiang Ai Qing Li Lihua Liu Xiehong Zhou Lin |
| author_facet | Xu Xinyu Zhou Jiang Ai Qing Li Lihua Liu Xiehong Zhou Lin |
| author_sort | Xu Xinyu |
| collection | DOAJ |
| description | Abstract To evaluate the clinical utility of PCT, CRP, IL-6, NLR, and TyG index in improving the early diagnosis and severity assessment of acute pancreatitis (AP). This retrospective study included 137 AP patients and 30 healthy controls from Hunan Provincial People’s Hospital (January 2021–September 2023). Univariate and multivariate logistic regression analyses assessed the associations between biomarkers and severe acute pancreatitis (SAP). Receiver operating characteristic (ROC) curves, DeLong test, and Bonferroni correction were used to evaluate predictive performance. Model robustness was validated via 5-fold cross-validation. PCT, CRP, IL-6, NLR, and TyG index levels were significantly elevated in AP patients compared to controls (P < 0.001) and correlated with disease severity (P < 0.05). CRP and NLR levels differed significantly among mild, moderate, and severe AP (P < 0.01). Alcohol consumption and hyperlipidemia were significantly linked to AP severity (P for trend < 0.0001). Multivariate analysis identified hyperlipidemia (OR = 3.030, P = 0.040), CRP (OR = 1.011, P < 0.001), and NLR (OR = 1.078, P = 0.020) as independent SAP predictors. The combined model of CRP + NLR + TyG achieved the highest AUC (0.882, sensitivity = 77.2%, specificity = 88.5%), though it was not significantly better than CRP + NLR or CRP + TyG models (P > 0.05). 5-fold cross-validation confirmed consistent performance (mean AUC = 0.817 ± 0.118). PCT, CRP, IL-6, NLR, and TyG index are valuable in diagnosing and assessing AP prognosis. Hyperlipidemia, CRP, and NLR are reliable independent predictors of SAP. Combining multiple biomarkers enhances diagnostic precision and provides guidance for personalized treatment strategies in AP. |
| format | Article |
| id | doaj-art-ec464d3915c94a11b66192a2b6f40cdd |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-ec464d3915c94a11b66192a2b6f40cdd2025-01-26T12:25:21ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-86664-xClinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysisXu Xinyu0Zhou Jiang1Ai Qing2Li Lihua3Liu Xiehong4Zhou Lin5College of Clinical Laboratory, Changsha Medical UniversityCollege of Clinical Laboratory, Changsha Medical UniversityChangsha Shanshui Medical Laboratory Co., LtdChangsha Shanshui Medical Laboratory Co., LtdDepartment of Cardiology, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University)College of Clinical Laboratory, Changsha Medical UniversityAbstract To evaluate the clinical utility of PCT, CRP, IL-6, NLR, and TyG index in improving the early diagnosis and severity assessment of acute pancreatitis (AP). This retrospective study included 137 AP patients and 30 healthy controls from Hunan Provincial People’s Hospital (January 2021–September 2023). Univariate and multivariate logistic regression analyses assessed the associations between biomarkers and severe acute pancreatitis (SAP). Receiver operating characteristic (ROC) curves, DeLong test, and Bonferroni correction were used to evaluate predictive performance. Model robustness was validated via 5-fold cross-validation. PCT, CRP, IL-6, NLR, and TyG index levels were significantly elevated in AP patients compared to controls (P < 0.001) and correlated with disease severity (P < 0.05). CRP and NLR levels differed significantly among mild, moderate, and severe AP (P < 0.01). Alcohol consumption and hyperlipidemia were significantly linked to AP severity (P for trend < 0.0001). Multivariate analysis identified hyperlipidemia (OR = 3.030, P = 0.040), CRP (OR = 1.011, P < 0.001), and NLR (OR = 1.078, P = 0.020) as independent SAP predictors. The combined model of CRP + NLR + TyG achieved the highest AUC (0.882, sensitivity = 77.2%, specificity = 88.5%), though it was not significantly better than CRP + NLR or CRP + TyG models (P > 0.05). 5-fold cross-validation confirmed consistent performance (mean AUC = 0.817 ± 0.118). PCT, CRP, IL-6, NLR, and TyG index are valuable in diagnosing and assessing AP prognosis. Hyperlipidemia, CRP, and NLR are reliable independent predictors of SAP. Combining multiple biomarkers enhances diagnostic precision and provides guidance for personalized treatment strategies in AP.https://doi.org/10.1038/s41598-025-86664-xAcute Pancreatitis (AP)C-Reactive protein (CRP)Procalcitonin (PCT)Interleukin-6 (IL-6)Neutrophil-to-lymphocyte ratio (NLR)Triglyceride-glucose index (TyG Index) |
| spellingShingle | Xu Xinyu Zhou Jiang Ai Qing Li Lihua Liu Xiehong Zhou Lin Clinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysis Scientific Reports Acute Pancreatitis (AP) C-Reactive protein (CRP) Procalcitonin (PCT) Interleukin-6 (IL-6) Neutrophil-to-lymphocyte ratio (NLR) Triglyceride-glucose index (TyG Index) |
| title | Clinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysis |
| title_full | Clinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysis |
| title_fullStr | Clinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysis |
| title_full_unstemmed | Clinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysis |
| title_short | Clinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysis |
| title_sort | clinical significance of pct crp il 6 nlr and tyg index in early diagnosis and severity assessment of acute pancreatitis a retrospective analysis |
| topic | Acute Pancreatitis (AP) C-Reactive protein (CRP) Procalcitonin (PCT) Interleukin-6 (IL-6) Neutrophil-to-lymphocyte ratio (NLR) Triglyceride-glucose index (TyG Index) |
| url | https://doi.org/10.1038/s41598-025-86664-x |
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