Mental Health Across the Metabolic Spectrum
Understanding the relationship between metabolism and mental health involves examining how disruptions in one system influence the other. The specific mechanisms by which metabolic processes impact the mind—and how mental well-being, in turn, affects metabolic regulation—are poorly understood. This...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Biological Psychiatry Global Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667174324001563 |
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| author | Vrinda Saxena Isaac Marin-Valencia |
| author_facet | Vrinda Saxena Isaac Marin-Valencia |
| author_sort | Vrinda Saxena |
| collection | DOAJ |
| description | Understanding the relationship between metabolism and mental health involves examining how disruptions in one system influence the other. The specific mechanisms by which metabolic processes impact the mind—and how mental well-being, in turn, affects metabolic regulation—are poorly understood. This shortcoming is attributable to the complex and multilayered nature of both the metabolic network and mental processes, as well as the lack of robust quantitative methods to analyze the workings of the mind. Inborn errors of metabolism exemplify this complexity, with over one-fourth being associated with psychiatric manifestations. Despite their high prevalence, psychiatric deficits in individuals with inborn errors of metabolism remain challenging to recognize and manage due to phenotypic variability, limited clinical training in neurometabolism, and gaps in research. To identify intersections between metabolism and mental health, here we assessed the effects of metabolic dysregulation on mental function, focusing on inborn errors of metabolism. |
| format | Article |
| id | doaj-art-ec445cd0d3a44d789ca5794acf21344c |
| institution | Kabale University |
| issn | 2667-1743 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biological Psychiatry Global Open Science |
| spelling | doaj-art-ec445cd0d3a44d789ca5794acf21344c2025-01-29T05:02:21ZengElsevierBiological Psychiatry Global Open Science2667-17432025-03-0152100443Mental Health Across the Metabolic SpectrumVrinda Saxena0Isaac Marin-Valencia1Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New YorkDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York; The Abimael Laboratory of Neurometabolism, Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York; Departments of Neuroscience, Genetics and Genomics Medicine, and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York; Address correspondence to Isaac Marin-Valencia, M.D., M.S.Understanding the relationship between metabolism and mental health involves examining how disruptions in one system influence the other. The specific mechanisms by which metabolic processes impact the mind—and how mental well-being, in turn, affects metabolic regulation—are poorly understood. This shortcoming is attributable to the complex and multilayered nature of both the metabolic network and mental processes, as well as the lack of robust quantitative methods to analyze the workings of the mind. Inborn errors of metabolism exemplify this complexity, with over one-fourth being associated with psychiatric manifestations. Despite their high prevalence, psychiatric deficits in individuals with inborn errors of metabolism remain challenging to recognize and manage due to phenotypic variability, limited clinical training in neurometabolism, and gaps in research. To identify intersections between metabolism and mental health, here we assessed the effects of metabolic dysregulation on mental function, focusing on inborn errors of metabolism.http://www.sciencedirect.com/science/article/pii/S2667174324001563Inborn errors of metabolismMentalMetabolismNeurodegenerationNeurodevelopmentPsychiatry |
| spellingShingle | Vrinda Saxena Isaac Marin-Valencia Mental Health Across the Metabolic Spectrum Biological Psychiatry Global Open Science Inborn errors of metabolism Mental Metabolism Neurodegeneration Neurodevelopment Psychiatry |
| title | Mental Health Across the Metabolic Spectrum |
| title_full | Mental Health Across the Metabolic Spectrum |
| title_fullStr | Mental Health Across the Metabolic Spectrum |
| title_full_unstemmed | Mental Health Across the Metabolic Spectrum |
| title_short | Mental Health Across the Metabolic Spectrum |
| title_sort | mental health across the metabolic spectrum |
| topic | Inborn errors of metabolism Mental Metabolism Neurodegeneration Neurodevelopment Psychiatry |
| url | http://www.sciencedirect.com/science/article/pii/S2667174324001563 |
| work_keys_str_mv | AT vrindasaxena mentalhealthacrossthemetabolicspectrum AT isaacmarinvalencia mentalhealthacrossthemetabolicspectrum |