Novel strategies to overcome tumor immunotherapy resistance using CAR NK cells

Novel strategies to overcome tumor immunotherapy resistance using CAR NK cells

While immunotherapy faces obstacles, the emergence of chimeric antigen receptor (CAR) engineered natural killer (NK) cells is paving new ways and might become a preferred option over CAR T cells very soon. CAR NK introduce diverse cytotoxic mechanisms offering novel strategies to combat tumor immuno...

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Bibliographic Details
Main Authors: Jun-Hui Guo, Ali Afzal, Sadia Ahmad, Ghazala Saeed, Amna Rehman, Umair Ali Khan Saddozai, Lei Liu, Shi-Hao Guo, Xin-Ying Ji, Muhammad Babar Khawar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
CAR NK cells
immunotherapy resistance
tumor microenvironment
NK cell homing
cancer immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1550652/full
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