The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats
Background. p38 mitogen-activated protein kinase (MAPK) plays a crucial role in regulating signaling pathways implicated in inflammatory processes leading to diabetic nephropathy (DN). This study aimed to examine p38 MAPK activation in DN and determine whether beraprost sodium (BPS) ameliorates DN b...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/1690474 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849690130101567488 |
|---|---|
| author | Li Peng Jie Li Yixing Xu Yangtian Wang Hong Du Jiaqing Shao Zhimin Liu |
| author_facet | Li Peng Jie Li Yixing Xu Yangtian Wang Hong Du Jiaqing Shao Zhimin Liu |
| author_sort | Li Peng |
| collection | DOAJ |
| description | Background. p38 mitogen-activated protein kinase (MAPK) plays a crucial role in regulating signaling pathways implicated in inflammatory processes leading to diabetic nephropathy (DN). This study aimed to examine p38 MAPK activation in DN and determine whether beraprost sodium (BPS) ameliorates DN by inhibiting inflammation and p38 MAPK signaling pathway in diabetic rats. Methods. Forty male Sprague Dawley (SD) rats were randomly divided into the normal control group, type 2 diabetic group, and BPS treatment group. At the end of the 8-week experiment, we measured renal pathological changes and the activation of the p38 MAPK signaling pathway and inflammation. Result. After BPS treatment, renal function, 24-hour urine protein, lipid profiles, and blood glucose level were improved significantly; meanwhile, inflammation and the expression of p38 MAPK signaling pathway in the diabetic kidney were attenuated. Conclusions. BPS significantly prevented type 2 diabetes induced kidney injury characterized by renal dysfunction and pathological changes. The protective mechanisms are complicated but may be mainly attributed to the inhibition of the p38 MAPK signaling pathway and inflammation in the diabetic kidney. |
| format | Article |
| id | doaj-art-ec33df8fb64f4e99adbf511ea5049e32 |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ec33df8fb64f4e99adbf511ea5049e322025-08-20T03:21:24ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/16904741690474The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic RatsLi Peng0Jie Li1Yixing Xu2Yangtian Wang3Hong Du4Jiaqing Shao5Zhimin Liu6Department of Endocrinology, Nanjing General Hospital of Nanjing Military Command (Jinling Hospital), 305 East Zhongshan Road, Nanjing, Jiangsu 210002, ChinaDepartment of Endocrinology, Nanjing General Hospital of Nanjing Military Command (Jinling Hospital), 305 East Zhongshan Road, Nanjing, Jiangsu 210002, ChinaDepartment of Endocrinology, Nanjing General Hospital of Nanjing Military Command (Jinling Hospital), 305 East Zhongshan Road, Nanjing, Jiangsu 210002, ChinaDepartment of Endocrinology, Nanjing General Hospital of Nanjing Military Command (Jinling Hospital), 305 East Zhongshan Road, Nanjing, Jiangsu 210002, ChinaDepartment of Endocrinology, Nanjing General Hospital of Nanjing Military Command (Jinling Hospital), 305 East Zhongshan Road, Nanjing, Jiangsu 210002, ChinaDepartment of Endocrinology, Nanjing General Hospital of Nanjing Military Command (Jinling Hospital), 305 East Zhongshan Road, Nanjing, Jiangsu 210002, ChinaDepartment of Endocrinology, Shanghai Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, ChinaBackground. p38 mitogen-activated protein kinase (MAPK) plays a crucial role in regulating signaling pathways implicated in inflammatory processes leading to diabetic nephropathy (DN). This study aimed to examine p38 MAPK activation in DN and determine whether beraprost sodium (BPS) ameliorates DN by inhibiting inflammation and p38 MAPK signaling pathway in diabetic rats. Methods. Forty male Sprague Dawley (SD) rats were randomly divided into the normal control group, type 2 diabetic group, and BPS treatment group. At the end of the 8-week experiment, we measured renal pathological changes and the activation of the p38 MAPK signaling pathway and inflammation. Result. After BPS treatment, renal function, 24-hour urine protein, lipid profiles, and blood glucose level were improved significantly; meanwhile, inflammation and the expression of p38 MAPK signaling pathway in the diabetic kidney were attenuated. Conclusions. BPS significantly prevented type 2 diabetes induced kidney injury characterized by renal dysfunction and pathological changes. The protective mechanisms are complicated but may be mainly attributed to the inhibition of the p38 MAPK signaling pathway and inflammation in the diabetic kidney.http://dx.doi.org/10.1155/2016/1690474 |
| spellingShingle | Li Peng Jie Li Yixing Xu Yangtian Wang Hong Du Jiaqing Shao Zhimin Liu The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats International Journal of Endocrinology |
| title | The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats |
| title_full | The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats |
| title_fullStr | The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats |
| title_full_unstemmed | The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats |
| title_short | The Protective Effect of Beraprost Sodium on Diabetic Nephropathy by Inhibiting Inflammation and p38 MAPK Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats |
| title_sort | protective effect of beraprost sodium on diabetic nephropathy by inhibiting inflammation and p38 mapk signaling pathway in high fat diet streptozotocin induced diabetic rats |
| url | http://dx.doi.org/10.1155/2016/1690474 |
| work_keys_str_mv | AT lipeng theprotectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats AT jieli theprotectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats AT yixingxu theprotectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats AT yangtianwang theprotectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats AT hongdu theprotectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats AT jiaqingshao theprotectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats AT zhiminliu theprotectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats AT lipeng protectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats AT jieli protectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats AT yixingxu protectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats AT yangtianwang protectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats AT hongdu protectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats AT jiaqingshao protectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats AT zhiminliu protectiveeffectofberaprostsodiumondiabeticnephropathybyinhibitinginflammationandp38mapksignalingpathwayinhighfatdietstreptozotocininduceddiabeticrats |