Formulation for Muscle Building and Mobility Improvement
A formulation composed of vitamin D (VD), calcium β-hydroxy-β-methylbutyrate (HMBCa), and medium-and long-chain triacylglycerols (MLCT) in a precise ratio of 1:350000:200000 was examined for its potential impacts on muscle development and enhancement of mobility. A zebrafish larval model of dexameth...
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| Format: | Article |
| Language: | zho |
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The editorial department of Science and Technology of Food Industry
2025-02-01
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| Series: | Shipin gongye ke-ji |
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| Online Access: | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024010195 |
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| author | Bingbing CAO Zhengdong LIU Huan GE Jiali ZHOU Xingwang YE Mingyuan QI Renyan LIU Yiqiao XU |
| author_facet | Bingbing CAO Zhengdong LIU Huan GE Jiali ZHOU Xingwang YE Mingyuan QI Renyan LIU Yiqiao XU |
| author_sort | Bingbing CAO |
| collection | DOAJ |
| description | A formulation composed of vitamin D (VD), calcium β-hydroxy-β-methylbutyrate (HMBCa), and medium-and long-chain triacylglycerols (MLCT) in a precise ratio of 1:350000:200000 was examined for its potential impacts on muscle development and enhancement of mobility. A zebrafish larval model of dexamethasone-induced sarcopenia was used to evaluate the formula's influence on muscle tissue morphology, myelin sheath fluorescence intensity, and the expression of muscle atrophy-related genes. Furthermore, a zebrafish fatigue model induced by sodium sulfite was utilized to assess the formula's effects on mobility, as well as levels of adenosine 5'-triphosphate (ATP), lactate, and reactive oxygen species (ROS) levels, thereby elucidating its impact on zebrafish locomotor behavior and underlying mechanisms. The results indicated that the formulation enhanced muscle fiber quality and improved muscle tissue structure in the zebrafish sarcopenia model. Further detailed studies uncovered that the formulation could stimulate myelin regeneration and suppress the expression of muscle atrophy-related genes (mstnb, myod1, trim63a, and fbxo32). Additionally, the concoction increased the activity level of zebrafish in a fatigue model. More detailed investigations revealed that the formulation could boost ATP production, reduce lactate accumulation, and enhance ROS scavenging in zebrafish. In conclusion, the formula demonstrates significant effects in fostering muscle development and enhancing mobility. |
| format | Article |
| id | doaj-art-ec33b953cd0d496b9b999651ba3cd8ca |
| institution | Kabale University |
| issn | 1002-0306 |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | The editorial department of Science and Technology of Food Industry |
| record_format | Article |
| series | Shipin gongye ke-ji |
| spelling | doaj-art-ec33b953cd0d496b9b999651ba3cd8ca2025-01-21T07:24:08ZzhoThe editorial department of Science and Technology of Food IndustryShipin gongye ke-ji1002-03062025-02-0146336837510.13386/j.issn1002-0306.20240101952024010195-3Formulation for Muscle Building and Mobility ImprovementBingbing CAO0Zhengdong LIU1Huan GE2Jiali ZHOU3Xingwang YE4Mingyuan QI5Renyan LIU6Yiqiao XU7Hunter Biotechnology, Inc., Hangzhou 310051, ChinaInner Mongolia Mengniu Dairy (Group) Co., Ltd., Huhhot 011500, ChinaHunter Biotechnology, Inc., Hangzhou 310051, ChinaHunter Biotechnology, Inc., Hangzhou 310051, ChinaInner Mongolia Mengniu Dairy (Group) Co., Ltd., Huhhot 011500, ChinaInner Mongolia Mengniu Dairy (Group) Co., Ltd., Huhhot 011500, ChinaHunter Biotechnology, Inc., Hangzhou 310051, ChinaHunter Biotechnology, Inc., Hangzhou 310051, ChinaA formulation composed of vitamin D (VD), calcium β-hydroxy-β-methylbutyrate (HMBCa), and medium-and long-chain triacylglycerols (MLCT) in a precise ratio of 1:350000:200000 was examined for its potential impacts on muscle development and enhancement of mobility. A zebrafish larval model of dexamethasone-induced sarcopenia was used to evaluate the formula's influence on muscle tissue morphology, myelin sheath fluorescence intensity, and the expression of muscle atrophy-related genes. Furthermore, a zebrafish fatigue model induced by sodium sulfite was utilized to assess the formula's effects on mobility, as well as levels of adenosine 5'-triphosphate (ATP), lactate, and reactive oxygen species (ROS) levels, thereby elucidating its impact on zebrafish locomotor behavior and underlying mechanisms. The results indicated that the formulation enhanced muscle fiber quality and improved muscle tissue structure in the zebrafish sarcopenia model. Further detailed studies uncovered that the formulation could stimulate myelin regeneration and suppress the expression of muscle atrophy-related genes (mstnb, myod1, trim63a, and fbxo32). Additionally, the concoction increased the activity level of zebrafish in a fatigue model. More detailed investigations revealed that the formulation could boost ATP production, reduce lactate accumulation, and enhance ROS scavenging in zebrafish. In conclusion, the formula demonstrates significant effects in fostering muscle development and enhancing mobility.http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024010195sarcopeniavitamin d (vd)calcium β-hydroxy-β-methylbutyrate (hmbca)medium-and long-chain triacylglycerols (mlct)zebrafish sarcopenia modelzebrafish fatigue model |
| spellingShingle | Bingbing CAO Zhengdong LIU Huan GE Jiali ZHOU Xingwang YE Mingyuan QI Renyan LIU Yiqiao XU Formulation for Muscle Building and Mobility Improvement Shipin gongye ke-ji sarcopenia vitamin d (vd) calcium β-hydroxy-β-methylbutyrate (hmbca) medium-and long-chain triacylglycerols (mlct) zebrafish sarcopenia model zebrafish fatigue model |
| title | Formulation for Muscle Building and Mobility Improvement |
| title_full | Formulation for Muscle Building and Mobility Improvement |
| title_fullStr | Formulation for Muscle Building and Mobility Improvement |
| title_full_unstemmed | Formulation for Muscle Building and Mobility Improvement |
| title_short | Formulation for Muscle Building and Mobility Improvement |
| title_sort | formulation for muscle building and mobility improvement |
| topic | sarcopenia vitamin d (vd) calcium β-hydroxy-β-methylbutyrate (hmbca) medium-and long-chain triacylglycerols (mlct) zebrafish sarcopenia model zebrafish fatigue model |
| url | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024010195 |
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