EPHA5 and SOD2 genetic variants and their link to neurofilament light chain: early detection of taxane-induced neurotoxicity in Egyptian breast cancer patients

EPHA5 and SOD2 genetic variants and their link to neurofilament light chain: early detection of taxane-induced neurotoxicity in Egyptian breast cancer patients

Abstract Background Breast cancer is the leading cause of cancer-related deaths globally, with taxanes being the most commonly used chemotherapeutic agents. However, adverse effects like myelosuppression, neuropathy, and hypersensitivity reactions exist. Objective To find the association between gen...

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Bibliographic Details
Main Authors: Amira B. Kassem, Amira Abdelmonem Ahmed, Noha A. El‑Bassiouny, Gamal Omran, Mahmoud Mohamed Kamel, Ahmed El Bastawisy, Nermeen Nabeel Abuelsoud
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Breast cancer
EPHA5
SOD2
Genetic polymorphisms
Neurotoxicity
Taxanes
Online Access:https://doi.org/10.1186/s43094-025-00827-1
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