Asymptomatic vivax malaria is associated with an IFN-γ-program on adaptive immunity

Asymptomatic vivax malaria is associated with an IFN-γ-program on adaptive immunity

Abstract The adaptive immunity against Plasmodium vivax is thought to be essential to limit parasite growth during asymptomatic malaria, preventing the occurrence of symptoms. However, the mechanisms governing clinical immunity during asymptomatic infections are not understood. Here, we investigated...

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Main Authors: Gregório Guilherme Almeida, Camila Medeiros Costa, Pedro Augusto Carvalho Costa, Gabriela Ribeiro Gomes, Maria Marta Figueiredo, Katherine Jéssica Torres, Alex Fiorini de Carvalho, Bruno Vinícius Santos Valiate, Julia Ramos Sampaio, Brener Cunha Carvalho, Dhelio Batista Pereira, Alexia Martines, Mauro Shugiro Tada, Irene Silva Soares, Jamie Ponmattam, Marcia Caldas de Castro, Douglas Taylor Golenbock, Ricardo Tostes Gazzinelli, Lis Ribeiro do Valle Antonelli
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Plasmodium vivax
Asymptomatic malaria
Malaria
CD4 T cells
B cells
Online Access:https://doi.org/10.1186/s12967-025-06353-1
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