Prevalence and features of allergic bronchopulmonary aspergillosis, United States, 2016-2022.
The epidemiology of allergic bronchopulmonary aspergillosis (ABPA) in the United States is not well-described. To estimate national ABPA prevalence among patients with asthma or cystic fibrosis, characterize ABPA testing practices, and describe ABPA clinical features, treatment, and 6-month outcomes...
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0317054 |
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| author | Kaitlin Benedict Jeremy A W Gold Mitsuru Toda Joy Hsu |
| author_facet | Kaitlin Benedict Jeremy A W Gold Mitsuru Toda Joy Hsu |
| author_sort | Kaitlin Benedict |
| collection | DOAJ |
| description | The epidemiology of allergic bronchopulmonary aspergillosis (ABPA) in the United States is not well-described. To estimate national ABPA prevalence among patients with asthma or cystic fibrosis, characterize ABPA testing practices, and describe ABPA clinical features, treatment, and 6-month outcomes. We used the 2016-2022 Merative™ MarketScan® Commercial/Medicare and Multi-State Medicaid Databases to identify cohorts of patients with 1) asthma, 2) cystic fibrosis (CF), and 3) ABPA. We calculated ABPA prevalence per 10,000 patients with asthma or CF, assessed diagnostic testing for ABPA among patients with severe asthma, and described features of patients with ABPA using diagnosis and procedure codes. The overall ABPA prevalence among patients with asthma was 2.8/10,000 (Commercial/Medicare) and 1.0/10,000 (Medicaid). ABPA prevalence increased with asthma severity (Commercial/Medicare: mild 1.3, moderate 9.3, severe 70.6, Medicaid: mild 0.3, moderate 2.4, severe 32.4). Among patients with CF, ABPA prevalence was 183.7/10,000 (Commercial/Medicare) and 134.6/10,000 (Medicaid). Among patients with severe asthma, 10.3% (Commercial/Medicare) and 7.4% (Medicaid) received total immunoglobulin E testing, which is recommended for ABPA diagnosis. Among all patients with ABPA (Commercial/Medicare: n = 1,564, Medicaid: n = 410), ABPA treatments included inhaled corticosteroids (>70%), systemic corticosteroids (>62%), and antifungals (>18%). Patients with ABPA and Medicaid were more likely to experience hospitalization (45.1% vs. 22.5% of patients with Commercial/Medicare insurance) and respiratory failure (18.5% vs. 10.9%). This analysis provides initial estimates of national ABPA prevalence. Further studies could identify potential barriers to ABPA testing and investigate potential factors affecting payer-related differences in ABPA burden. |
| format | Article |
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| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-ec2151125fb74ee09d050b6abfacbc642025-02-05T05:31:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031705410.1371/journal.pone.0317054Prevalence and features of allergic bronchopulmonary aspergillosis, United States, 2016-2022.Kaitlin BenedictJeremy A W GoldMitsuru TodaJoy HsuThe epidemiology of allergic bronchopulmonary aspergillosis (ABPA) in the United States is not well-described. To estimate national ABPA prevalence among patients with asthma or cystic fibrosis, characterize ABPA testing practices, and describe ABPA clinical features, treatment, and 6-month outcomes. We used the 2016-2022 Merative™ MarketScan® Commercial/Medicare and Multi-State Medicaid Databases to identify cohorts of patients with 1) asthma, 2) cystic fibrosis (CF), and 3) ABPA. We calculated ABPA prevalence per 10,000 patients with asthma or CF, assessed diagnostic testing for ABPA among patients with severe asthma, and described features of patients with ABPA using diagnosis and procedure codes. The overall ABPA prevalence among patients with asthma was 2.8/10,000 (Commercial/Medicare) and 1.0/10,000 (Medicaid). ABPA prevalence increased with asthma severity (Commercial/Medicare: mild 1.3, moderate 9.3, severe 70.6, Medicaid: mild 0.3, moderate 2.4, severe 32.4). Among patients with CF, ABPA prevalence was 183.7/10,000 (Commercial/Medicare) and 134.6/10,000 (Medicaid). Among patients with severe asthma, 10.3% (Commercial/Medicare) and 7.4% (Medicaid) received total immunoglobulin E testing, which is recommended for ABPA diagnosis. Among all patients with ABPA (Commercial/Medicare: n = 1,564, Medicaid: n = 410), ABPA treatments included inhaled corticosteroids (>70%), systemic corticosteroids (>62%), and antifungals (>18%). Patients with ABPA and Medicaid were more likely to experience hospitalization (45.1% vs. 22.5% of patients with Commercial/Medicare insurance) and respiratory failure (18.5% vs. 10.9%). This analysis provides initial estimates of national ABPA prevalence. Further studies could identify potential barriers to ABPA testing and investigate potential factors affecting payer-related differences in ABPA burden.https://doi.org/10.1371/journal.pone.0317054 |
| spellingShingle | Kaitlin Benedict Jeremy A W Gold Mitsuru Toda Joy Hsu Prevalence and features of allergic bronchopulmonary aspergillosis, United States, 2016-2022. PLoS ONE |
| title | Prevalence and features of allergic bronchopulmonary aspergillosis, United States, 2016-2022. |
| title_full | Prevalence and features of allergic bronchopulmonary aspergillosis, United States, 2016-2022. |
| title_fullStr | Prevalence and features of allergic bronchopulmonary aspergillosis, United States, 2016-2022. |
| title_full_unstemmed | Prevalence and features of allergic bronchopulmonary aspergillosis, United States, 2016-2022. |
| title_short | Prevalence and features of allergic bronchopulmonary aspergillosis, United States, 2016-2022. |
| title_sort | prevalence and features of allergic bronchopulmonary aspergillosis united states 2016 2022 |
| url | https://doi.org/10.1371/journal.pone.0317054 |
| work_keys_str_mv | AT kaitlinbenedict prevalenceandfeaturesofallergicbronchopulmonaryaspergillosisunitedstates20162022 AT jeremyawgold prevalenceandfeaturesofallergicbronchopulmonaryaspergillosisunitedstates20162022 AT mitsurutoda prevalenceandfeaturesofallergicbronchopulmonaryaspergillosisunitedstates20162022 AT joyhsu prevalenceandfeaturesofallergicbronchopulmonaryaspergillosisunitedstates20162022 |