Heterogeneous focal adhesion cytoskeleton nanoarchitectures from microengineered interfacial curvature to oversee nuclear remodeling and mechanotransduction of mesenchymal stem cells

Heterogeneous focal adhesion cytoskeleton nanoarchitectures from microengineered interfacial curvature to oversee nuclear remodeling and mechanotransduction of mesenchymal stem cells

Abstract Background Interfacial heterogeneity is widely explored to reveal molecular mechanisms of force-mediated pathways due to biased tension. However, the influence of cell density,, curvature, and interfacial heterogeneity on underlying pathways of mechanotransduction is obscure. Methods Polydi...

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Bibliographic Details
Main Authors: Huayu Fan, Hui Zhao, Yan Hou, Danni Meng, Jizong Jiang, Eon-Bee Lee, Yinzheng Fu, Xiangdong Zhang, Rui Chen, Yongtao Wang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cellular & Molecular Biology Letters
Subjects:
Cell colony
Interfacial heterogeneity
Focal adhesion
Cytoskeleton tension
Nuclear mechanotransduction
Online Access:https://doi.org/10.1186/s11658-025-00692-z
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