Breast tumors from ATM pathogenic variant carriers display a specific genome-wide DNA methylation profile

Breast tumors from ATM pathogenic variant carriers display a specific genome-wide DNA methylation profile

Abstract Background The ataxia-telangiectasia mutated (ATM) kinase phosphorylates and activates several downstream targets that are essential for DNA damage repair, cell cycle inhibition and apoptosis. Germline biallelic inactivation of the ATM gene causes ataxia-telangiectasia (A-T), and heterozygo...

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Main Authors: Nicolas M. Viart, Anne-Laure Renault, Séverine Eon-Marchais, Yue Jiao, Laetitia Fuhrmann, Sophia Murat El Houdigui, Dorothée Le Gal, Eve Cavaciuti, Marie-Gabrielle Dondon, Juana Beauvallet, Virginie Raynal, Dominique Stoppa-Lyonnet, Anne Vincent-Salomon, Nadine Andrieu, Melissa C. Southey, Fabienne Lesueur
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Breast Cancer Research
Subjects:
Breast cancer
ATM gene
Epigenetics
DNA methylation
Biomarker
Molecular testing
Online Access:https://doi.org/10.1186/s13058-025-01988-w
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