Green Chemistry Within the Circular Bioeconomy to Harness Chestnut Burr Extract’s Synergistic Antimicrobial Activity Against <i>Helicobacter pylori</i>
Green chemistry principles are pivotal in driving sustainable and innovative solutions to global health challenges. This study explores a hydroalcoholic extract from <i>Castanea sativa</i> (chestnut) burrs, an underutilized natural resource, as a potent source of antimicrobial compounds...
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MDPI AG
2025-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/2/324 |
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| author | Maria Lucia Schiavone Roberta Barletta Alfonso Trezza Michela Geminiani Lia Millucci Natale Figura Annalisa Santucci |
| author_facet | Maria Lucia Schiavone Roberta Barletta Alfonso Trezza Michela Geminiani Lia Millucci Natale Figura Annalisa Santucci |
| author_sort | Maria Lucia Schiavone |
| collection | DOAJ |
| description | Green chemistry principles are pivotal in driving sustainable and innovative solutions to global health challenges. This study explores a hydroalcoholic extract from <i>Castanea sativa</i> (chestnut) burrs, an underutilized natural resource, as a potent source of antimicrobial compounds against <i>Helicobacter pylori</i> (<i>H. pylori</i>). The extract demonstrated significant bactericidal activity, synergizing effectively with clarithromycin and showing additive effects with metronidazole. Remarkably, combining the extract with clarithromycin and sub-inhibitory concentrations of pantoprazole reduced clarithromycin’s Minimum Bactericidal Concentration (MBC) to just 1.56% of its original value. Mechanistic studies suggest that the extract’s polyphenolic compounds compromise bacterial membrane integrity, enhancing antibiotic uptake, while pantoprazole disrupts bacterial ATPase activity. This research highlights the critical role of natural product extraction within the framework of green chemistry, offering a sustainable and environmentally friendly alternative to synthetic antimicrobials. By harnessing bioactive compounds from plant sources, this approach addresses the pressing issue of antibiotic resistance while promoting the responsible use of natural resources. The findings underscore the transformative potential of green chemistry in developing effective, eco-conscious antimicrobial therapies that align with global sustainability goals. |
| format | Article |
| id | doaj-art-ec0ef1c35e8a474fa886f5c099d6b0e8 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-ec0ef1c35e8a474fa886f5c099d6b0e82025-01-24T13:43:36ZengMDPI AGMolecules1420-30492025-01-0130232410.3390/molecules30020324Green Chemistry Within the Circular Bioeconomy to Harness Chestnut Burr Extract’s Synergistic Antimicrobial Activity Against <i>Helicobacter pylori</i>Maria Lucia Schiavone0Roberta Barletta1Alfonso Trezza2Michela Geminiani3Lia Millucci4Natale Figura5Annalisa Santucci6Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro, 53100 Siena, ItalyDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro, 53100 Siena, ItalyDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro, 53100 Siena, ItalyDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro, 53100 Siena, ItalyDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro, 53100 Siena, ItalyDepartment of Medical, Surgical and Neurological Sciences, University of Siena and Policlinico S. Maria alle Scotte, 53100 Siena, ItalyDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro, 53100 Siena, ItalyGreen chemistry principles are pivotal in driving sustainable and innovative solutions to global health challenges. This study explores a hydroalcoholic extract from <i>Castanea sativa</i> (chestnut) burrs, an underutilized natural resource, as a potent source of antimicrobial compounds against <i>Helicobacter pylori</i> (<i>H. pylori</i>). The extract demonstrated significant bactericidal activity, synergizing effectively with clarithromycin and showing additive effects with metronidazole. Remarkably, combining the extract with clarithromycin and sub-inhibitory concentrations of pantoprazole reduced clarithromycin’s Minimum Bactericidal Concentration (MBC) to just 1.56% of its original value. Mechanistic studies suggest that the extract’s polyphenolic compounds compromise bacterial membrane integrity, enhancing antibiotic uptake, while pantoprazole disrupts bacterial ATPase activity. This research highlights the critical role of natural product extraction within the framework of green chemistry, offering a sustainable and environmentally friendly alternative to synthetic antimicrobials. By harnessing bioactive compounds from plant sources, this approach addresses the pressing issue of antibiotic resistance while promoting the responsible use of natural resources. The findings underscore the transformative potential of green chemistry in developing effective, eco-conscious antimicrobial therapies that align with global sustainability goals.https://www.mdpi.com/1420-3049/30/2/324chestnut burrscircular bioeconomyMBCantimicrobial activity<i>Helicobacter pylori</i> |
| spellingShingle | Maria Lucia Schiavone Roberta Barletta Alfonso Trezza Michela Geminiani Lia Millucci Natale Figura Annalisa Santucci Green Chemistry Within the Circular Bioeconomy to Harness Chestnut Burr Extract’s Synergistic Antimicrobial Activity Against <i>Helicobacter pylori</i> Molecules chestnut burrs circular bioeconomy MBC antimicrobial activity <i>Helicobacter pylori</i> |
| title | Green Chemistry Within the Circular Bioeconomy to Harness Chestnut Burr Extract’s Synergistic Antimicrobial Activity Against <i>Helicobacter pylori</i> |
| title_full | Green Chemistry Within the Circular Bioeconomy to Harness Chestnut Burr Extract’s Synergistic Antimicrobial Activity Against <i>Helicobacter pylori</i> |
| title_fullStr | Green Chemistry Within the Circular Bioeconomy to Harness Chestnut Burr Extract’s Synergistic Antimicrobial Activity Against <i>Helicobacter pylori</i> |
| title_full_unstemmed | Green Chemistry Within the Circular Bioeconomy to Harness Chestnut Burr Extract’s Synergistic Antimicrobial Activity Against <i>Helicobacter pylori</i> |
| title_short | Green Chemistry Within the Circular Bioeconomy to Harness Chestnut Burr Extract’s Synergistic Antimicrobial Activity Against <i>Helicobacter pylori</i> |
| title_sort | green chemistry within the circular bioeconomy to harness chestnut burr extract s synergistic antimicrobial activity against i helicobacter pylori i |
| topic | chestnut burrs circular bioeconomy MBC antimicrobial activity <i>Helicobacter pylori</i> |
| url | https://www.mdpi.com/1420-3049/30/2/324 |
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