Potential roles of cigarette smoking on gut microbiota profile among Chinese men
Abstract Background Cigarette smoking is posited as a potential factor in disrupting the balance of the human gut microbiota. However, existing studies with limited sample size have yielded inconclusive results. Methods Here, we assessed the association between cigarette smoking and gut microbial pr...
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BMC
2025-01-01
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| Online Access: | https://doi.org/10.1186/s12916-025-03852-2 |
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| author | Jiayao Fan Fangfang Zeng Haili Zhong Jun Cai Wentao Shen Chunxiao Cheng Chunfeng He Yuanjiao Liu Yuan Zhou Shujie Chen Yimin Zhu Tao Liu Ju-Sheng Zheng Lan Wang Yu-Ming Chen Wenjun Ma Dan Zhou |
| author_facet | Jiayao Fan Fangfang Zeng Haili Zhong Jun Cai Wentao Shen Chunxiao Cheng Chunfeng He Yuanjiao Liu Yuan Zhou Shujie Chen Yimin Zhu Tao Liu Ju-Sheng Zheng Lan Wang Yu-Ming Chen Wenjun Ma Dan Zhou |
| author_sort | Jiayao Fan |
| collection | DOAJ |
| description | Abstract Background Cigarette smoking is posited as a potential factor in disrupting the balance of the human gut microbiota. However, existing studies with limited sample size have yielded inconclusive results. Methods Here, we assessed the association between cigarette smoking and gut microbial profile among Chinese males from four independent studies (N total = 3308). Both 16S rRNA and shotgun metagenomic sequencing methods were employed, covering 206 genera and 237 species. Microbial diversity and abundance were compared among non-smokers, current smokers, and former smokers. Results Actinomyces[g], Atopobium[g], Haemophilus[g], Turicibacter[g], and Lachnospira[g] were found to be associated with smoking status (current smokers vs. non-smokers). Metagenomic data provided a higher resolution at the species level, particularly for the Actinomyces[g] branch. Additionally, serum γ-glutamylcysteine (γ-Glu-Cys) was found to have a potential role in connecting smoking and Actinomyces[g]. Furthermore, we revealed putative mediation roles of the gut microbiome in the associations between smoking and common diseases including cholecystitis and type 2 diabetes. Conclusions We characterized the gut microbiota profile in male smokers and further revealed their potential involvement in mediating the impact of smoking on health outcomes. These findings advance our understanding of the intricate association between cigarette smoking and the gut microbiome. |
| format | Article |
| id | doaj-art-ec0e91be36b84d679cbd724d5522d361 |
| institution | Kabale University |
| issn | 1741-7015 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj-art-ec0e91be36b84d679cbd724d5522d3612025-01-26T12:37:17ZengBMCBMC Medicine1741-70152025-01-0123111810.1186/s12916-025-03852-2Potential roles of cigarette smoking on gut microbiota profile among Chinese menJiayao Fan0Fangfang Zeng1Haili Zhong2Jun Cai3Wentao Shen4Chunxiao Cheng5Chunfeng He6Yuanjiao Liu7Yuan Zhou8Shujie Chen9Yimin Zhu10Tao Liu11Ju-Sheng Zheng12Lan Wang13Yu-Ming Chen14Wenjun Ma15Dan Zhou16The Second Affiliated Hospital, School of Public Health, Zhejiang University School of MedicineDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan UniversityGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Epidemiology, School of Public Health, Sun Yat-Sen UniversityDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan UniversityDepartment of Gastroenterology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang UniversityThe Second Affiliated Hospital, School of Public Health, Zhejiang University School of MedicineThe Second Affiliated Hospital, School of Public Health, Zhejiang University School of MedicineDepartment of Epidemiology & Biostatistics, School of Public Health, Zhejiang UniversityThe Second Affiliated Hospital, School of Public Health, Zhejiang University School of MedicineDepartment of Gastroenterology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang UniversityDepartment of Epidemiology & Biostatistics, School of Public Health, Zhejiang UniversityDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan UniversityInstitute of Basic Medical Sciences, Westlake Institute for Advanced StudyDepartment of Gastroenterology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang UniversityGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Epidemiology, School of Public Health, Sun Yat-Sen UniversityDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan UniversityThe Second Affiliated Hospital, School of Public Health, Zhejiang University School of MedicineAbstract Background Cigarette smoking is posited as a potential factor in disrupting the balance of the human gut microbiota. However, existing studies with limited sample size have yielded inconclusive results. Methods Here, we assessed the association between cigarette smoking and gut microbial profile among Chinese males from four independent studies (N total = 3308). Both 16S rRNA and shotgun metagenomic sequencing methods were employed, covering 206 genera and 237 species. Microbial diversity and abundance were compared among non-smokers, current smokers, and former smokers. Results Actinomyces[g], Atopobium[g], Haemophilus[g], Turicibacter[g], and Lachnospira[g] were found to be associated with smoking status (current smokers vs. non-smokers). Metagenomic data provided a higher resolution at the species level, particularly for the Actinomyces[g] branch. Additionally, serum γ-glutamylcysteine (γ-Glu-Cys) was found to have a potential role in connecting smoking and Actinomyces[g]. Furthermore, we revealed putative mediation roles of the gut microbiome in the associations between smoking and common diseases including cholecystitis and type 2 diabetes. Conclusions We characterized the gut microbiota profile in male smokers and further revealed their potential involvement in mediating the impact of smoking on health outcomes. These findings advance our understanding of the intricate association between cigarette smoking and the gut microbiome.https://doi.org/10.1186/s12916-025-03852-2Cigarette smokingGut microbiotaChineseMale population |
| spellingShingle | Jiayao Fan Fangfang Zeng Haili Zhong Jun Cai Wentao Shen Chunxiao Cheng Chunfeng He Yuanjiao Liu Yuan Zhou Shujie Chen Yimin Zhu Tao Liu Ju-Sheng Zheng Lan Wang Yu-Ming Chen Wenjun Ma Dan Zhou Potential roles of cigarette smoking on gut microbiota profile among Chinese men BMC Medicine Cigarette smoking Gut microbiota Chinese Male population |
| title | Potential roles of cigarette smoking on gut microbiota profile among Chinese men |
| title_full | Potential roles of cigarette smoking on gut microbiota profile among Chinese men |
| title_fullStr | Potential roles of cigarette smoking on gut microbiota profile among Chinese men |
| title_full_unstemmed | Potential roles of cigarette smoking on gut microbiota profile among Chinese men |
| title_short | Potential roles of cigarette smoking on gut microbiota profile among Chinese men |
| title_sort | potential roles of cigarette smoking on gut microbiota profile among chinese men |
| topic | Cigarette smoking Gut microbiota Chinese Male population |
| url | https://doi.org/10.1186/s12916-025-03852-2 |
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