Updates on the development of vaccines and therapeutic options against rabies
Even though rabies has been claiming more than 50,000 deaths annually worldwide, it is considered as a vaccine-preventable viral disease. More than 95 % of the total human rabies cases are caused by dogs. During the initial stage of infection, affected individuals usually show weakess at the bitten...
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| Format: | Article |
| Language: | English |
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HH Publisher
2020-08-01
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| Series: | Progress in Microbes and Molecular Biology |
| Online Access: | https://journals.hh-publisher.com/index.php/pmmb/article/view/306 |
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| author | Roshan Arjun Ananda Hooi-Leng Ser Vengadesh Letchumanan |
| author_facet | Roshan Arjun Ananda Hooi-Leng Ser Vengadesh Letchumanan |
| author_sort | Roshan Arjun Ananda |
| collection | DOAJ |
| description |
Even though rabies has been claiming more than 50,000 deaths annually worldwide, it is considered as a vaccine-preventable viral disease. More than 95 % of the total human rabies cases are caused by dogs. During the initial stage of infection, affected individuals usually show weakess at the bitten extremities and the virus can ultimately travel to the brain causing neurological signs. In attenuated (inactivated) form, the currently in use vaccines have been recommended by WHO for the prevention (i.e. pre-exposure prophylaxis, PrEP) and treatment (i.e. post-exposure prophylaxis, PEP) regime against
the rabies virus (RABV). However, given that they normally require refrigeration and are costly, there have been discussions revolving around potential development of newer, safer and cheaper alternative that can perform better and more convenient than the ones that are currently in use. The current review aims to explore general characteristics of RABV before looking into potential candidates of vaccines that have been studied. Further studies on the pathogenic mechanism of RABV and therapeutic approaches are still required to prevent the deathly infection following clinical manifestation. In sum, integrated interventional strategy emphasizing human health and animal health is essential and requires collaboration between health authorities and the public.
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| format | Article |
| id | doaj-art-ec0cf0d344694dc6bd878fad692d313c |
| institution | Kabale University |
| issn | 2637-1049 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | HH Publisher |
| record_format | Article |
| series | Progress in Microbes and Molecular Biology |
| spelling | doaj-art-ec0cf0d344694dc6bd878fad692d313c2025-02-04T08:37:02ZengHH PublisherProgress in Microbes and Molecular Biology2637-10492020-08-013110.36877/pmmb.a0000100Updates on the development of vaccines and therapeutic options against rabies Roshan Arjun AnandaHooi-Leng SerVengadesh Letchumanan Even though rabies has been claiming more than 50,000 deaths annually worldwide, it is considered as a vaccine-preventable viral disease. More than 95 % of the total human rabies cases are caused by dogs. During the initial stage of infection, affected individuals usually show weakess at the bitten extremities and the virus can ultimately travel to the brain causing neurological signs. In attenuated (inactivated) form, the currently in use vaccines have been recommended by WHO for the prevention (i.e. pre-exposure prophylaxis, PrEP) and treatment (i.e. post-exposure prophylaxis, PEP) regime against the rabies virus (RABV). However, given that they normally require refrigeration and are costly, there have been discussions revolving around potential development of newer, safer and cheaper alternative that can perform better and more convenient than the ones that are currently in use. The current review aims to explore general characteristics of RABV before looking into potential candidates of vaccines that have been studied. Further studies on the pathogenic mechanism of RABV and therapeutic approaches are still required to prevent the deathly infection following clinical manifestation. In sum, integrated interventional strategy emphasizing human health and animal health is essential and requires collaboration between health authorities and the public. https://journals.hh-publisher.com/index.php/pmmb/article/view/306 |
| spellingShingle | Roshan Arjun Ananda Hooi-Leng Ser Vengadesh Letchumanan Updates on the development of vaccines and therapeutic options against rabies Progress in Microbes and Molecular Biology |
| title | Updates on the development of vaccines and therapeutic options against rabies |
| title_full | Updates on the development of vaccines and therapeutic options against rabies |
| title_fullStr | Updates on the development of vaccines and therapeutic options against rabies |
| title_full_unstemmed | Updates on the development of vaccines and therapeutic options against rabies |
| title_short | Updates on the development of vaccines and therapeutic options against rabies |
| title_sort | updates on the development of vaccines and therapeutic options against rabies |
| url | https://journals.hh-publisher.com/index.php/pmmb/article/view/306 |
| work_keys_str_mv | AT roshanarjunananda updatesonthedevelopmentofvaccinesandtherapeuticoptionsagainstrabies AT hooilengser updatesonthedevelopmentofvaccinesandtherapeuticoptionsagainstrabies AT vengadeshletchumanan updatesonthedevelopmentofvaccinesandtherapeuticoptionsagainstrabies |