Regulatory T cells crosstalk with tumor cells and endothelium through lymphotoxin signaling

Regulatory T cells crosstalk with tumor cells and endothelium through lymphotoxin signaling

Abstract Regulatory T cells (Tregs) with multifaceted functions suppress anti-tumor immunity by signaling surrounding cells. Here we report Tregs use the surface lymphotoxin (LT)α1β2 to preferentially stimulate LT beta receptor (LTβR) nonclassical NFκB signaling on both tumor cells and lymphatic end...

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Main Authors: Wenji Piao, Long Wu, Yanbao Xiong, Gregory C. Zapas, Christina M. Paluskievicz, Robert S. Oakes, Sarah M. Pettit, Margaret L. Sleeth, Keli L. Hippen, Jessica Schmitz, Philipp Ivanyi, Amol C. Shetty, Yang Song, Dejun Kong, Young Lee, Lushen Li, Marina W. Shirkey, Allison Kensiski, Aamna Alvi, Kevin Ho, Vikas Saxena, Jan H. Bräsen, Christopher M. Jewell, Bruce R. Blazar, Reza Abdi, Jonathan S. Bromberg
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54874-y
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