CT Imaging Findings after Stereotactic Radiotherapy for Liver Tumors
Purpose. To study radiological response to stereotactic radiotherapy for focal liver tumors. Materials and Methods. In this IRB-approved, HIPAA-compliant study CTs of 68 consecutive patients who underwent stereotactic radiotherapy for liver tumors between 01/2006 and 01/2010 were retrospectively rev...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/126245 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552676134486016 |
|---|---|
| author | Olga R. Brook Eavan Thornton Mishal Mendiratta-Lala Anand Mahadevan Vassilious Raptopoulos Alexander Brook Robert Najarian Robert Sheiman Bettina Siewert |
| author_facet | Olga R. Brook Eavan Thornton Mishal Mendiratta-Lala Anand Mahadevan Vassilious Raptopoulos Alexander Brook Robert Najarian Robert Sheiman Bettina Siewert |
| author_sort | Olga R. Brook |
| collection | DOAJ |
| description | Purpose. To study radiological response to stereotactic radiotherapy for focal liver tumors. Materials and Methods. In this IRB-approved, HIPAA-compliant study CTs of 68 consecutive patients who underwent stereotactic radiotherapy for liver tumors between 01/2006 and 01/2010 were retrospectively reviewed. Two independent reviewers evaluated lesion volume and enhancement pattern of the lesion and of juxtaposed liver parenchyma. Results. 36 subjects with hepatocellular carcinoma (HCC), 25 with liver metastases, and seven with cholangiocarcinoma (CCC) were included in study. Mean follow-up time was 5.6 ± 7.1 months for HCC, 6.4 ± 5.1 months for metastases, and 10.1 ± 4.8 months for the CCC. Complete response was seen in 4/36 (11.1%) HCCs and 1/25 (4%) metastases. Partial response (>30% decrease in long diameter) was seen in 25/36 (69%) HCCs, 14/25 (58%) metastases, and 7/7 (100%) of CCCs. Partial response followed by local recurrence (>20% increase in long diameter from nadir) occurred in 2/36 (6%) HCCs and 4/25 (17%) metastases. Liver parenchyma adjacent to the lesion demonstrated a prominent halo of delayed enhancement in 27/36 (78%) of HCCs, 19/21 (91%) of metastases, and 7/7 (100%) of CCCs. Conclusion. Sustainable radiological partial response to stereotactic radiotherapy is most frequent outcome seen in liver lesions. Prominent halo of delayed enhancement of the adjacent liver is frequent finding. |
| format | Article |
| id | doaj-art-ec0639aeeb6c465c8a22af846528afd0 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ec0639aeeb6c465c8a22af846528afd02025-02-03T05:58:15ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/126245126245CT Imaging Findings after Stereotactic Radiotherapy for Liver TumorsOlga R. Brook0Eavan Thornton1Mishal Mendiratta-Lala2Anand Mahadevan3Vassilious Raptopoulos4Alexander Brook5Robert Najarian6Robert Sheiman7Bettina Siewert8Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USADepartment of Radiology, Beaumont Hospital, Dublin, IrelandHenry Ford Hospital, Diagnostic Radiology, 2799 West Grand Boulevard, Detroit, MI 48202, USADepartment of Radiation Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USADepartment of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USADepartment of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USADepartment of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USADepartment of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USADepartment of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USAPurpose. To study radiological response to stereotactic radiotherapy for focal liver tumors. Materials and Methods. In this IRB-approved, HIPAA-compliant study CTs of 68 consecutive patients who underwent stereotactic radiotherapy for liver tumors between 01/2006 and 01/2010 were retrospectively reviewed. Two independent reviewers evaluated lesion volume and enhancement pattern of the lesion and of juxtaposed liver parenchyma. Results. 36 subjects with hepatocellular carcinoma (HCC), 25 with liver metastases, and seven with cholangiocarcinoma (CCC) were included in study. Mean follow-up time was 5.6 ± 7.1 months for HCC, 6.4 ± 5.1 months for metastases, and 10.1 ± 4.8 months for the CCC. Complete response was seen in 4/36 (11.1%) HCCs and 1/25 (4%) metastases. Partial response (>30% decrease in long diameter) was seen in 25/36 (69%) HCCs, 14/25 (58%) metastases, and 7/7 (100%) of CCCs. Partial response followed by local recurrence (>20% increase in long diameter from nadir) occurred in 2/36 (6%) HCCs and 4/25 (17%) metastases. Liver parenchyma adjacent to the lesion demonstrated a prominent halo of delayed enhancement in 27/36 (78%) of HCCs, 19/21 (91%) of metastases, and 7/7 (100%) of CCCs. Conclusion. Sustainable radiological partial response to stereotactic radiotherapy is most frequent outcome seen in liver lesions. Prominent halo of delayed enhancement of the adjacent liver is frequent finding.http://dx.doi.org/10.1155/2015/126245 |
| spellingShingle | Olga R. Brook Eavan Thornton Mishal Mendiratta-Lala Anand Mahadevan Vassilious Raptopoulos Alexander Brook Robert Najarian Robert Sheiman Bettina Siewert CT Imaging Findings after Stereotactic Radiotherapy for Liver Tumors Gastroenterology Research and Practice |
| title | CT Imaging Findings after Stereotactic Radiotherapy for Liver Tumors |
| title_full | CT Imaging Findings after Stereotactic Radiotherapy for Liver Tumors |
| title_fullStr | CT Imaging Findings after Stereotactic Radiotherapy for Liver Tumors |
| title_full_unstemmed | CT Imaging Findings after Stereotactic Radiotherapy for Liver Tumors |
| title_short | CT Imaging Findings after Stereotactic Radiotherapy for Liver Tumors |
| title_sort | ct imaging findings after stereotactic radiotherapy for liver tumors |
| url | http://dx.doi.org/10.1155/2015/126245 |
| work_keys_str_mv | AT olgarbrook ctimagingfindingsafterstereotacticradiotherapyforlivertumors AT eavanthornton ctimagingfindingsafterstereotacticradiotherapyforlivertumors AT mishalmendirattalala ctimagingfindingsafterstereotacticradiotherapyforlivertumors AT anandmahadevan ctimagingfindingsafterstereotacticradiotherapyforlivertumors AT vassiliousraptopoulos ctimagingfindingsafterstereotacticradiotherapyforlivertumors AT alexanderbrook ctimagingfindingsafterstereotacticradiotherapyforlivertumors AT robertnajarian ctimagingfindingsafterstereotacticradiotherapyforlivertumors AT robertsheiman ctimagingfindingsafterstereotacticradiotherapyforlivertumors AT bettinasiewert ctimagingfindingsafterstereotacticradiotherapyforlivertumors |