Analysis of Retinal Thickness in Patients With Chronic Diseases Using Standardized Optical Coherence Tomography Data: Database Study Based on the Radiology Common Data Model
Abstract BackgroundThe Observational Medical Outcome Partners-Common Data Model (OMOP-CDM) is an international standard for harmonizing electronic medical record (EMR) data. However, since it does not standardize unstructured data, such as medical imaging, using this data in m...
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JMIR Publications
2025-02-01
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| Series: | JMIR Medical Informatics |
| Online Access: | https://medinform.jmir.org/2025/1/e64422 |
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| author | ChulHyoung Park So Hee Lee Da Yun Lee Seoyoon Choi Seng Chan You Ja Young Jeon Sang Jun Park Rae Woong Park |
| author_facet | ChulHyoung Park So Hee Lee Da Yun Lee Seoyoon Choi Seng Chan You Ja Young Jeon Sang Jun Park Rae Woong Park |
| author_sort | ChulHyoung Park |
| collection | DOAJ |
| description |
Abstract
BackgroundThe Observational Medical Outcome Partners-Common Data Model (OMOP-CDM) is an international standard for harmonizing electronic medical record (EMR) data. However, since it does not standardize unstructured data, such as medical imaging, using this data in multi-institutional collaborative research becomes challenging. To overcome this limitation, extensions such as the Radiology Common Data Model (R-CDM) have emerged to include and standardize these data types.
ObjectiveThis work aims to demonstrate that by standardizing optical coherence tomography (OCT) data into an R-CDM format, multi-institutional collaborative studies analyzing changes in retinal thickness in patients with long-standing chronic diseases can be performed efficiently.
MethodsWe standardized OCT images collected from two tertiary hospitals for research purposes using the R-CDM. As a proof of concept, we conducted a comparative analysis of retinal thickness between patients who have chronic diseases and those who have not. Patients diagnosed or treated for retinal and choroidal diseases, which could affect retinal thickness, were excluded from the analysis. Using the existing OMOP-CDM at each institution, we extracted cohorts of patients with chronic diseases and control groups, performing large-scale 1:2 propensity score matching (PSM). Subsequently, we linked the OMOP-CDM and R-CDM to extract the OCT image data of these cohorts and analyzed central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness using a linear mixed model.
ResultsOCT data of 261,874 images from Ajou University Medical Center (AUMC) and 475,626 images from Seoul National University Bundang Hospital (SNUBH) were standardized in the R-CDM format. The R-CDM databases established at each institution were linked with the OMOP-CDM database. Following 1:2 PSM, the type 2 diabetes mellitus (T2DM) cohort included 957 patients, and the control cohort had 1603 patients. During the follow-up period, significant reductions in CMT were observed in the T2DM cohorts at AUMC (PPPPP
ConclusionsThe significance of our study lies in demonstrating the efficiency of multi-institutional collaborative research that simultaneously uses clinical data and medical imaging data by leveraging the OMOP-CDM for standardizing EMR data and the R-CDM for standardizing medical imaging data. |
| format | Article |
| id | doaj-art-ec00d2187b364c15a78bd810979c4466 |
| institution | DOAJ |
| issn | 2291-9694 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR Medical Informatics |
| spelling | doaj-art-ec00d2187b364c15a78bd810979c44662025-08-20T02:54:58ZengJMIR PublicationsJMIR Medical Informatics2291-96942025-02-0113e64422e6442210.2196/64422Analysis of Retinal Thickness in Patients With Chronic Diseases Using Standardized Optical Coherence Tomography Data: Database Study Based on the Radiology Common Data ModelChulHyoung Parkhttp://orcid.org/0000-0003-0531-9144So Hee Leehttp://orcid.org/0009-0007-5030-9320Da Yun Leehttp://orcid.org/0000-0002-9604-8337Seoyoon Choihttp://orcid.org/0009-0009-0621-6412Seng Chan Youhttp://orcid.org/0000-0002-5052-6399Ja Young Jeonhttp://orcid.org/0000-0002-3877-0479Sang Jun Parkhttp://orcid.org/0000-0003-0542-2758Rae Woong Parkhttp://orcid.org/0000-0003-4989-3287 Abstract BackgroundThe Observational Medical Outcome Partners-Common Data Model (OMOP-CDM) is an international standard for harmonizing electronic medical record (EMR) data. However, since it does not standardize unstructured data, such as medical imaging, using this data in multi-institutional collaborative research becomes challenging. To overcome this limitation, extensions such as the Radiology Common Data Model (R-CDM) have emerged to include and standardize these data types. ObjectiveThis work aims to demonstrate that by standardizing optical coherence tomography (OCT) data into an R-CDM format, multi-institutional collaborative studies analyzing changes in retinal thickness in patients with long-standing chronic diseases can be performed efficiently. MethodsWe standardized OCT images collected from two tertiary hospitals for research purposes using the R-CDM. As a proof of concept, we conducted a comparative analysis of retinal thickness between patients who have chronic diseases and those who have not. Patients diagnosed or treated for retinal and choroidal diseases, which could affect retinal thickness, were excluded from the analysis. Using the existing OMOP-CDM at each institution, we extracted cohorts of patients with chronic diseases and control groups, performing large-scale 1:2 propensity score matching (PSM). Subsequently, we linked the OMOP-CDM and R-CDM to extract the OCT image data of these cohorts and analyzed central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness using a linear mixed model. ResultsOCT data of 261,874 images from Ajou University Medical Center (AUMC) and 475,626 images from Seoul National University Bundang Hospital (SNUBH) were standardized in the R-CDM format. The R-CDM databases established at each institution were linked with the OMOP-CDM database. Following 1:2 PSM, the type 2 diabetes mellitus (T2DM) cohort included 957 patients, and the control cohort had 1603 patients. During the follow-up period, significant reductions in CMT were observed in the T2DM cohorts at AUMC (PPPPP ConclusionsThe significance of our study lies in demonstrating the efficiency of multi-institutional collaborative research that simultaneously uses clinical data and medical imaging data by leveraging the OMOP-CDM for standardizing EMR data and the R-CDM for standardizing medical imaging data.https://medinform.jmir.org/2025/1/e64422 |
| spellingShingle | ChulHyoung Park So Hee Lee Da Yun Lee Seoyoon Choi Seng Chan You Ja Young Jeon Sang Jun Park Rae Woong Park Analysis of Retinal Thickness in Patients With Chronic Diseases Using Standardized Optical Coherence Tomography Data: Database Study Based on the Radiology Common Data Model JMIR Medical Informatics |
| title | Analysis of Retinal Thickness in Patients With Chronic Diseases Using Standardized Optical Coherence Tomography Data: Database Study Based on the Radiology Common Data Model |
| title_full | Analysis of Retinal Thickness in Patients With Chronic Diseases Using Standardized Optical Coherence Tomography Data: Database Study Based on the Radiology Common Data Model |
| title_fullStr | Analysis of Retinal Thickness in Patients With Chronic Diseases Using Standardized Optical Coherence Tomography Data: Database Study Based on the Radiology Common Data Model |
| title_full_unstemmed | Analysis of Retinal Thickness in Patients With Chronic Diseases Using Standardized Optical Coherence Tomography Data: Database Study Based on the Radiology Common Data Model |
| title_short | Analysis of Retinal Thickness in Patients With Chronic Diseases Using Standardized Optical Coherence Tomography Data: Database Study Based on the Radiology Common Data Model |
| title_sort | analysis of retinal thickness in patients with chronic diseases using standardized optical coherence tomography data database study based on the radiology common data model |
| url | https://medinform.jmir.org/2025/1/e64422 |
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