AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid Accumulation and Insulin Resistance in HL-1 Cardiac Cells by Inducing PPAR-Target Gene Expression

AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid Accumulation and Insulin Resistance in HL-1 Cardiac Cells by Inducing PPAR-Target Gene Expression

Here we studied the impact of 5-aminoimidazole-4-carboxamide riboside (AICAR), a well-known AMPK activator, on cardiac metabolic adaptation. AMPK activation by AICAR was confirmed by increased phospho-Thr172-AMPK and phospho-Ser79-ACC protein levels in HL-1 cardiomyocytes. Then, cells were exposed t...

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Bibliographic Details
Main Authors: Ricardo Rodríguez-Calvo, Manuel Vázquez-Carrera, Luis Masana, Dietbert Neumann
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2015/785783
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