Multiple sclerosis: report on 200 cases from Curitiba, Southern Brazil and comparison with other Brazilian series
We reviewed the clinical and laboratorial findings of 200 patients in Curitiba, Southern Brazil (25°25'40" S; 49°16'23" W-GR), with multiple sclerosis (MS)according to Poser's criteria. The patients were classified as: clinically definite (A1 and A2) - 142 patients (71%); la...
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Thieme Revinter Publicações
2001-06-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000200002&tlng=en |
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| author | Walter Oleschko Arruda Rosana Herminia Scola Hélio A. G. Teive Lineu C. Werneck |
| author_facet | Walter Oleschko Arruda Rosana Herminia Scola Hélio A. G. Teive Lineu C. Werneck |
| author_sort | Walter Oleschko Arruda |
| collection | DOAJ |
| description | We reviewed the clinical and laboratorial findings of 200 patients in Curitiba, Southern Brazil (25°25'40" S; 49°16'23" W-GR), with multiple sclerosis (MS)according to Poser's criteria. The patients were classified as: clinically definite (A1 and A2) - 142 patients (71%); laboratory-supported definite - 42 patients (21%); and clinically probable - 16 patients (8%). Relapsing-remitting (RR) form was the most common clinical presentation, with 182 (91%), followed by primary progressive (PP)(16 cases, 8%), and only 2 cases with secondarily progressive form (SP). Nine women and 7 men totalized the 16 PP cases. The mean age of onset was 32.0±9.9 (median 32 years). The gender ratio was female 1.8:1 male. All patients, except 3 African-Brazilian, were white. Seven (3.5%) patients developed a clinical history of Devic's syndrome. The initial clinical picture included brainstem/cerebellar syndrome in 126 (63%) cases, sensorial findings in 106 (53%)patients, motor (pyramidal) syndrome in 102 (49.5%), and optic neuritis in 79 (39.5%) cases. 122 (61%) patients had a final EDSS score < 3.5; 45 (22.5%) a score between 3.5 and 5.5, and 33 (16.5%) a score > or = 6.0. There was no significant correlation between the number of relapses or duration of disease with EDSS scores (Spearman's test). Only 14 (7%) of the total number presented the benign form (EDSS< 3.5 after 10 years of disease). We observed a later age of onset and initial clinical findings with higher frequency of brainstem/cerebellar syndrome and optic neuritis, when compared to other Brazilian and Western series |
| format | Article |
| id | doaj-art-ebf7c4bb1d104a52924e7d59eaa2c10f |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2001-06-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-ebf7c4bb1d104a52924e7d59eaa2c10f2025-08-20T03:21:17ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272001-06-01592A16517010.1590/S0004-282X2001000200002Multiple sclerosis: report on 200 cases from Curitiba, Southern Brazil and comparison with other Brazilian seriesWalter Oleschko Arruda0Rosana Herminia Scola1Hélio A. G. Teive2Lineu C. Werneck3Universidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáUniversidade Federal do ParanáWe reviewed the clinical and laboratorial findings of 200 patients in Curitiba, Southern Brazil (25°25'40" S; 49°16'23" W-GR), with multiple sclerosis (MS)according to Poser's criteria. The patients were classified as: clinically definite (A1 and A2) - 142 patients (71%); laboratory-supported definite - 42 patients (21%); and clinically probable - 16 patients (8%). Relapsing-remitting (RR) form was the most common clinical presentation, with 182 (91%), followed by primary progressive (PP)(16 cases, 8%), and only 2 cases with secondarily progressive form (SP). Nine women and 7 men totalized the 16 PP cases. The mean age of onset was 32.0±9.9 (median 32 years). The gender ratio was female 1.8:1 male. All patients, except 3 African-Brazilian, were white. Seven (3.5%) patients developed a clinical history of Devic's syndrome. The initial clinical picture included brainstem/cerebellar syndrome in 126 (63%) cases, sensorial findings in 106 (53%)patients, motor (pyramidal) syndrome in 102 (49.5%), and optic neuritis in 79 (39.5%) cases. 122 (61%) patients had a final EDSS score < 3.5; 45 (22.5%) a score between 3.5 and 5.5, and 33 (16.5%) a score > or = 6.0. There was no significant correlation between the number of relapses or duration of disease with EDSS scores (Spearman's test). Only 14 (7%) of the total number presented the benign form (EDSS< 3.5 after 10 years of disease). We observed a later age of onset and initial clinical findings with higher frequency of brainstem/cerebellar syndrome and optic neuritis, when compared to other Brazilian and Western serieshttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000200002&tlng=enmultiple sclerosisclinical formsBrazilian seriesEDSS |
| spellingShingle | Walter Oleschko Arruda Rosana Herminia Scola Hélio A. G. Teive Lineu C. Werneck Multiple sclerosis: report on 200 cases from Curitiba, Southern Brazil and comparison with other Brazilian series Arquivos de Neuro-Psiquiatria multiple sclerosis clinical forms Brazilian series EDSS |
| title | Multiple sclerosis: report on 200 cases from Curitiba, Southern Brazil and comparison with other Brazilian series |
| title_full | Multiple sclerosis: report on 200 cases from Curitiba, Southern Brazil and comparison with other Brazilian series |
| title_fullStr | Multiple sclerosis: report on 200 cases from Curitiba, Southern Brazil and comparison with other Brazilian series |
| title_full_unstemmed | Multiple sclerosis: report on 200 cases from Curitiba, Southern Brazil and comparison with other Brazilian series |
| title_short | Multiple sclerosis: report on 200 cases from Curitiba, Southern Brazil and comparison with other Brazilian series |
| title_sort | multiple sclerosis report on 200 cases from curitiba southern brazil and comparison with other brazilian series |
| topic | multiple sclerosis clinical forms Brazilian series EDSS |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000200002&tlng=en |
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