Systemic immune-inflammation index as a prognostic marker for chronic Hepatitis B with non-alcoholic fatty liver disease.
Introduction: This study investigates the association between high-level systemic immune-inflammatory index (SII) and cirrhosis progression in patients with chronic hepatitis B (CHB) and non-alcoholic fatty liver disease (NAFLD). Methodology: A total of 272 CHB patients with NAFLD treated at Jinc...
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The Journal of Infection in Developing Countries
2025-02-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/19636 |
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| author | Bo Xue Zeyu Wang Jianguo Li |
| author_facet | Bo Xue Zeyu Wang Jianguo Li |
| author_sort | Bo Xue |
| collection | DOAJ |
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Introduction: This study investigates the association between high-level systemic immune-inflammatory index (SII) and cirrhosis progression in patients with chronic hepatitis B (CHB) and non-alcoholic fatty liver disease (NAFLD).
Methodology: A total of 272 CHB patients with NAFLD treated at Jincheng General Hospital between January 2018 and January 2023 were included. The study endpoint was the development of cirrhosis. The optimal SII cut-off value for predicting cirrhosis progression was determined as 1024 using ROC curve analysis and Youden index. Based on this cut-off, patients were classified into low SII (n = 159) and high SII (n = 113) groups. Univariate and multivariate Cox regression analyses were performed to identify independent predictors of cirrhosis progression and assess the relationship with SII.
Results: Univariate Cox analysis revealed that SII was a significant risk factor for cirrhosis progression in CHB with NAFLD (HR = 2.062, 95% CI: 1.717-3.941, p < 0.001). Multivariate Cox regression analysis demonstrated a significant association between elevated SII levels and increased incidence of cirrhosis, with patients in the high SII group having an 88.5% higher risk (HR = 1.885, 95% CI: 1.167-3.045, p = 0.010). Kaplan-Meier survival analysis further confirmed the higher risk of cirrhosis in patients with high SII levels (log-rank p < 0.001) within 60 months.
Conclusions: This study suggests that SII is a relevant risk factor for cirrhosis development in CHB individuals with NAFLD, emphasizing the importance of considering SII in current clinical management.
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| format | Article |
| id | doaj-art-ebf1c439d2d04387a4422ac4ca4dfd7d |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | The Journal of Infection in Developing Countries |
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| spelling | doaj-art-ebf1c439d2d04387a4422ac4ca4dfd7d2025-08-20T02:16:02ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802025-02-01190210.3855/jidc.19636Systemic immune-inflammation index as a prognostic marker for chronic Hepatitis B with non-alcoholic fatty liver disease.Bo Xue0Zeyu Wang1Jianguo Li2Shanxi Medical University, Taiyuan, Shanxi Province, ChinaFuwai Hospital Chinese Academy of Medical Sciences, Bei Jing, ChinaShanxi Medical University, Taiyuan, Shanxi Province, China Introduction: This study investigates the association between high-level systemic immune-inflammatory index (SII) and cirrhosis progression in patients with chronic hepatitis B (CHB) and non-alcoholic fatty liver disease (NAFLD). Methodology: A total of 272 CHB patients with NAFLD treated at Jincheng General Hospital between January 2018 and January 2023 were included. The study endpoint was the development of cirrhosis. The optimal SII cut-off value for predicting cirrhosis progression was determined as 1024 using ROC curve analysis and Youden index. Based on this cut-off, patients were classified into low SII (n = 159) and high SII (n = 113) groups. Univariate and multivariate Cox regression analyses were performed to identify independent predictors of cirrhosis progression and assess the relationship with SII. Results: Univariate Cox analysis revealed that SII was a significant risk factor for cirrhosis progression in CHB with NAFLD (HR = 2.062, 95% CI: 1.717-3.941, p < 0.001). Multivariate Cox regression analysis demonstrated a significant association between elevated SII levels and increased incidence of cirrhosis, with patients in the high SII group having an 88.5% higher risk (HR = 1.885, 95% CI: 1.167-3.045, p = 0.010). Kaplan-Meier survival analysis further confirmed the higher risk of cirrhosis in patients with high SII levels (log-rank p < 0.001) within 60 months. Conclusions: This study suggests that SII is a relevant risk factor for cirrhosis development in CHB individuals with NAFLD, emphasizing the importance of considering SII in current clinical management. https://jidc.org/index.php/journal/article/view/19636Chronic viral hepatitis Bnon-alcoholic fatty liver diseasesystemic immune-inflammatory indexcirrhosis |
| spellingShingle | Bo Xue Zeyu Wang Jianguo Li Systemic immune-inflammation index as a prognostic marker for chronic Hepatitis B with non-alcoholic fatty liver disease. Journal of Infection in Developing Countries Chronic viral hepatitis B non-alcoholic fatty liver disease systemic immune-inflammatory index cirrhosis |
| title | Systemic immune-inflammation index as a prognostic marker for chronic Hepatitis B with non-alcoholic fatty liver disease. |
| title_full | Systemic immune-inflammation index as a prognostic marker for chronic Hepatitis B with non-alcoholic fatty liver disease. |
| title_fullStr | Systemic immune-inflammation index as a prognostic marker for chronic Hepatitis B with non-alcoholic fatty liver disease. |
| title_full_unstemmed | Systemic immune-inflammation index as a prognostic marker for chronic Hepatitis B with non-alcoholic fatty liver disease. |
| title_short | Systemic immune-inflammation index as a prognostic marker for chronic Hepatitis B with non-alcoholic fatty liver disease. |
| title_sort | systemic immune inflammation index as a prognostic marker for chronic hepatitis b with non alcoholic fatty liver disease |
| topic | Chronic viral hepatitis B non-alcoholic fatty liver disease systemic immune-inflammatory index cirrhosis |
| url | https://jidc.org/index.php/journal/article/view/19636 |
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