Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer: A Case Report and Review of the Literature
We report the case of a 65-year-old woman, diagnosed with a breast cancer human epidermal growth factor receptor (HER2) previously negative, who developed leptomeningeal carcinomatosis and was treated with intrathecal (IT) trastuzumab (TST). After five doses of IT trastuzumab, at escalading doses, o...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/154674 |
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| _version_ | 1832548985525501952 |
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| author | Cristina Dumitrescu Dominique Lossignol |
| author_facet | Cristina Dumitrescu Dominique Lossignol |
| author_sort | Cristina Dumitrescu |
| collection | DOAJ |
| description | We report the case of a 65-year-old woman, diagnosed with a breast cancer human epidermal growth factor receptor (HER2) previously negative, who developed leptomeningeal carcinomatosis and was treated with intrathecal (IT) trastuzumab (TST). After five doses of IT trastuzumab, at escalading doses, once weekly, the patient's neurological status stabilised, and that result was maintained for two months. There is evidence in the literature that breast cancer receptor status may change over time, and when it occurs, it may modify the therapeutical approach. We reviewed the pertinent literature and concluded that IT trastuzumab might be a promising treatment for patients with HER2-positive breast cancer leptomeningeal carcinomatosis. |
| format | Article |
| id | doaj-art-ebedafd34ba74cc382e323c9c3944588 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-ebedafd34ba74cc382e323c9c39445882025-02-03T06:12:34ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/154674154674Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer: A Case Report and Review of the LiteratureCristina Dumitrescu0Dominique Lossignol1 Department of Medical Oncology, Jules Bordet Institute, Boulevard de Waterloo, 121, 1000 Brussels, BelgiumSupportive Care Unit, Jules Bordet Institute, Boulevard de Waterloo, 121, 1000 Brussels, BelgiumWe report the case of a 65-year-old woman, diagnosed with a breast cancer human epidermal growth factor receptor (HER2) previously negative, who developed leptomeningeal carcinomatosis and was treated with intrathecal (IT) trastuzumab (TST). After five doses of IT trastuzumab, at escalading doses, once weekly, the patient's neurological status stabilised, and that result was maintained for two months. There is evidence in the literature that breast cancer receptor status may change over time, and when it occurs, it may modify the therapeutical approach. We reviewed the pertinent literature and concluded that IT trastuzumab might be a promising treatment for patients with HER2-positive breast cancer leptomeningeal carcinomatosis.http://dx.doi.org/10.1155/2013/154674 |
| spellingShingle | Cristina Dumitrescu Dominique Lossignol Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer: A Case Report and Review of the Literature Case Reports in Oncological Medicine |
| title | Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer: A Case Report and Review of the Literature |
| title_full | Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer: A Case Report and Review of the Literature |
| title_fullStr | Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer: A Case Report and Review of the Literature |
| title_full_unstemmed | Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer: A Case Report and Review of the Literature |
| title_short | Intrathecal Trastuzumab Treatment of the Neoplastic Meningitis due to Breast Cancer: A Case Report and Review of the Literature |
| title_sort | intrathecal trastuzumab treatment of the neoplastic meningitis due to breast cancer a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2013/154674 |
| work_keys_str_mv | AT cristinadumitrescu intrathecaltrastuzumabtreatmentoftheneoplasticmeningitisduetobreastcanceracasereportandreviewoftheliterature AT dominiquelossignol intrathecaltrastuzumabtreatmentoftheneoplasticmeningitisduetobreastcanceracasereportandreviewoftheliterature |