The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction
Purpose. This study is aimed at evaluating the clinicopathological features and prognostic significance of gastric outlet obstruction (GOO) in patients with distal gastric cancer. Methods. A retrospective review of 1564 individuals with distal gastric cancer from 2002 to 2010 was performed. In total...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/6529563 |
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| author | Hongliang Zu Huiling Wang Chunfeng Li Wendian Zhu Yingwei Xue |
| author_facet | Hongliang Zu Huiling Wang Chunfeng Li Wendian Zhu Yingwei Xue |
| author_sort | Hongliang Zu |
| collection | DOAJ |
| description | Purpose. This study is aimed at evaluating the clinicopathological features and prognostic significance of gastric outlet obstruction (GOO) in patients with distal gastric cancer. Methods. A retrospective review of 1564 individuals with distal gastric cancer from 2002 to 2010 was performed. In total, 157 patients had GOO. The clinicopathological features of the patients with GOO were compared with those of the patients without GOO. A Kaplan-Meier survival analysis and Cox proportional hazard model were used to assess the overall survival. Results. The patients with distal gastric cancer with GOO generally presented more aggressive pathologic features, a poorer nutritional status, more duodenal infiltration, and peritoneal dissemination than those with cancer without GOO. In the univariate analysis, curability, GOO, age, prealbumin, albumin, hemoglobin (Hb), the tumor size, the macroscopic type, lymph node metastasis, and the depth of invasion had a statistically significant influence on prognosis. The multivariate analysis showed that curability, GOO, the tumor size, lymph node metastasis, and the depth of invasion were independent prognostic factors. Conclusions. Gastric cancer with GOO exhibits aggressive biological features and has poor outcomes. The multivariate analysis showed that curability, GOO, the tumor size, lymph node metastasis, and the depth of invasion were independent prognostic factors. The gastric outlet status should be considered in the selection of surgical treatment methods for patients with gastric cancer. |
| format | Article |
| id | doaj-art-ebeb151852a44466bc4fbee1e5348a4e |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ebeb151852a44466bc4fbee1e5348a4e2025-02-03T01:05:04ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/65295636529563The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet ObstructionHongliang Zu0Huiling Wang1Chunfeng Li2Wendian Zhu3Yingwei Xue4Department of Gastroenterologic Surgery, The First People’s Hospital of Zhaoqing, ChinaDepartment of ICU, The First People’s Hospital of Zhaoqing, ChinaDepartment of Gastroenterologic Surgery, Affiliated Tumor Hospital of Harbin Medical University, ChinaDepartment of Gastroenterologic Surgery, The First People’s Hospital of Zhaoqing, ChinaDepartment of Gastroenterologic Surgery, Affiliated Tumor Hospital of Harbin Medical University, ChinaPurpose. This study is aimed at evaluating the clinicopathological features and prognostic significance of gastric outlet obstruction (GOO) in patients with distal gastric cancer. Methods. A retrospective review of 1564 individuals with distal gastric cancer from 2002 to 2010 was performed. In total, 157 patients had GOO. The clinicopathological features of the patients with GOO were compared with those of the patients without GOO. A Kaplan-Meier survival analysis and Cox proportional hazard model were used to assess the overall survival. Results. The patients with distal gastric cancer with GOO generally presented more aggressive pathologic features, a poorer nutritional status, more duodenal infiltration, and peritoneal dissemination than those with cancer without GOO. In the univariate analysis, curability, GOO, age, prealbumin, albumin, hemoglobin (Hb), the tumor size, the macroscopic type, lymph node metastasis, and the depth of invasion had a statistically significant influence on prognosis. The multivariate analysis showed that curability, GOO, the tumor size, lymph node metastasis, and the depth of invasion were independent prognostic factors. Conclusions. Gastric cancer with GOO exhibits aggressive biological features and has poor outcomes. The multivariate analysis showed that curability, GOO, the tumor size, lymph node metastasis, and the depth of invasion were independent prognostic factors. The gastric outlet status should be considered in the selection of surgical treatment methods for patients with gastric cancer.http://dx.doi.org/10.1155/2020/6529563 |
| spellingShingle | Hongliang Zu Huiling Wang Chunfeng Li Wendian Zhu Yingwei Xue The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction Gastroenterology Research and Practice |
| title | The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction |
| title_full | The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction |
| title_fullStr | The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction |
| title_full_unstemmed | The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction |
| title_short | The Predictive and Prognostic Factors in Patients with Gastric Cancer Accompanied by Gastric Outlet Obstruction |
| title_sort | predictive and prognostic factors in patients with gastric cancer accompanied by gastric outlet obstruction |
| url | http://dx.doi.org/10.1155/2020/6529563 |
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