Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model

Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model

Most human pancreatic ductal adenocarcinoma (PDAC) are not infiltrated with cytotoxic T cells and are highly resistant to immunotherapy. Over 90% of PDAC have oncogenic KRAS mutations, and phosphoinositide 3-kinases (PI3Ks) are direct effectors of KRAS. Our previous study demonstrated that ablation...

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Bibliographic Details
Main Authors: Han V Han, Richard Efem, Barbara Rosati, Kevin Lu, Sara Maimouni, Ya-Ping Jiang, Valeria Montoya, Ando Van Der Velden, Wei-Xing Zong, Richard Z Lin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-03-01
Series:eLife
Subjects:
pancreatic cancer
KPC cells
CD8 T cells
PD1
Online Access:https://elifesciences.org/articles/96925
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