Early innate immune response and evolution of a SARS-CoV-2 furin cleavage site inactive variant in bat cells

Early innate immune response and evolution of a SARS-CoV-2 furin cleavage site inactive variant in bat cells

Summary: SARS-CoV-2 has caused the largest known coronavirus pandemic and is believed to have emerged from insectivorous bats. Little is known about the evolution of these viruses in their reservoir bat species. In this study, we investigate the SARS-CoV-2-host interaction using human and bat cells....

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Main Authors: Kaushal Baid, Sauhard Shrivastava, Jessica Luc, Daniel Richard, Jennifer A. Aguiar, Yoan Machado, Sophie-Marie Aicher, Kimberley C. Siwak, Emmanuelle V. LeBlanc, Zahed Khatooni, Kumari G. Lokugamage, Michelle N. Vu, Angelica Morgan, Arkadeb Bhuinya, Kim R. Chiok, Hai T. Nguyen, Hannah D. Stacey, Erin Scruten, Tracy Prysliak, Winfield Yim, Andrew G. McArthur, Matthew S. Miller, Heather L. Wilson, Terence Capellini, Paul A. Faure, Qiang Liu, Samira Mubareka, Vineet D. Menachery, Karen Mossman, Marcel A. Müller, Christian Drosten, Che C. Colpitts, Nolwenn Jouvenet, Christopher M. Overall, Andrew C. Doxey, Arinjay Banerjee
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007004
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