Evolutionary conservation analysis of human sphingomyelin metabolism pathway genes
Sphingomyelin is an important member of the sphingolipid family and was first reported more than a century ago. It has been demonstrated that sphingomyelin plays a crucial role in compositing cell membranes and signaling pathways. Despite extensive functional studies on the sphingolipid metabolism p...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024168417 |
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| author | Siyuan Wang Huan Jiang Moran Hu Yingyun Gong Hongwen Zhou |
| author_facet | Siyuan Wang Huan Jiang Moran Hu Yingyun Gong Hongwen Zhou |
| author_sort | Siyuan Wang |
| collection | DOAJ |
| description | Sphingomyelin is an important member of the sphingolipid family and was first reported more than a century ago. It has been demonstrated that sphingomyelin plays a crucial role in compositing cell membranes and signaling pathways. Despite extensive functional studies on the sphingolipid metabolism pathway genes, one intriguing question remains: how does the emergence of these genes during evolution correlate with the acquisition of new functions in different species? By employing an evolutionary conservation analysis, the sequence of occurrence of biological processes during evolutionary history can be elucidated. Here we summarize and analyze the conservation status of the genes involved in sphingomyelin metabolism. |
| format | Article |
| id | doaj-art-ebe62c25e2ef4231b6b4148ca111bb0c |
| institution | OA Journals |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-ebe62c25e2ef4231b6b4148ca111bb0c2025-08-20T01:59:34ZengElsevierHeliyon2405-84402024-12-011023e4081010.1016/j.heliyon.2024.e40810Evolutionary conservation analysis of human sphingomyelin metabolism pathway genesSiyuan Wang0Huan Jiang1Moran Hu2Yingyun Gong3Hongwen Zhou4Department of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, ChinaDepartment of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, ChinaDepartment of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, ChinaCorresponding author.; Department of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, ChinaCorresponding author.; Department of Endocrinology and Metabolism, the First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, ChinaSphingomyelin is an important member of the sphingolipid family and was first reported more than a century ago. It has been demonstrated that sphingomyelin plays a crucial role in compositing cell membranes and signaling pathways. Despite extensive functional studies on the sphingolipid metabolism pathway genes, one intriguing question remains: how does the emergence of these genes during evolution correlate with the acquisition of new functions in different species? By employing an evolutionary conservation analysis, the sequence of occurrence of biological processes during evolutionary history can be elucidated. Here we summarize and analyze the conservation status of the genes involved in sphingomyelin metabolism.http://www.sciencedirect.com/science/article/pii/S2405844024168417SphingomyelinCeramidede novo synthesis pathwaySalvage synthesis pathwayInterspecies conservation status |
| spellingShingle | Siyuan Wang Huan Jiang Moran Hu Yingyun Gong Hongwen Zhou Evolutionary conservation analysis of human sphingomyelin metabolism pathway genes Heliyon Sphingomyelin Ceramide de novo synthesis pathway Salvage synthesis pathway Interspecies conservation status |
| title | Evolutionary conservation analysis of human sphingomyelin metabolism pathway genes |
| title_full | Evolutionary conservation analysis of human sphingomyelin metabolism pathway genes |
| title_fullStr | Evolutionary conservation analysis of human sphingomyelin metabolism pathway genes |
| title_full_unstemmed | Evolutionary conservation analysis of human sphingomyelin metabolism pathway genes |
| title_short | Evolutionary conservation analysis of human sphingomyelin metabolism pathway genes |
| title_sort | evolutionary conservation analysis of human sphingomyelin metabolism pathway genes |
| topic | Sphingomyelin Ceramide de novo synthesis pathway Salvage synthesis pathway Interspecies conservation status |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024168417 |
| work_keys_str_mv | AT siyuanwang evolutionaryconservationanalysisofhumansphingomyelinmetabolismpathwaygenes AT huanjiang evolutionaryconservationanalysisofhumansphingomyelinmetabolismpathwaygenes AT moranhu evolutionaryconservationanalysisofhumansphingomyelinmetabolismpathwaygenes AT yingyungong evolutionaryconservationanalysisofhumansphingomyelinmetabolismpathwaygenes AT hongwenzhou evolutionaryconservationanalysisofhumansphingomyelinmetabolismpathwaygenes |