Deficient AMPK-SENP1-Sirt3 signaling impairs mitochondrial complex I function in Parkinson’s disease model

Deficient AMPK-SENP1-Sirt3 signaling impairs mitochondrial complex I function in Parkinson’s disease model

Abstract Background Epidemiological studies have revealed increased Parkinson’s disease (PD) risk among individuals exposed to pesticides like 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MPTP is frequently used to induce PD-like symptoms in research models by disrupting mitochondrial comple...

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Bibliographic Details
Main Authors: Xiaoyu Sun, Jianyi Shen, Yimei Shu, Tianshi Wang, Lu He, Ruinan Shen, Yifan Zhou, Jinke Cheng, Suzhen Lin, Jianqing Ding
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Translational Neurodegeneration
Subjects:
Parkinson's disease
SENP1
Sirt3
Mitochondrial complex I
MPTP
Online Access:https://doi.org/10.1186/s40035-025-00489-2
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