Long-Term Clinical Behavior of Jejunoileal Involvement in Crohn’s Disease
Diffuse and extensive jejunoileal Crohn's disease is an uncommon entity. In 39 patients, including 21 males and 18 females, followed for a mean duration of over 16 years between 1979 and 2004, the extent of disease was defined and disease behaviour characterized. Over 80% of patients had concom...
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2005/647459 |
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| author | Hugh J Freeman |
| author_facet | Hugh J Freeman |
| author_sort | Hugh J Freeman |
| collection | DOAJ |
| description | Diffuse and extensive jejunoileal Crohn's disease is an uncommon entity. In 39 patients, including 21 males and 18 females, followed for a mean duration of over 16 years between 1979 and 2004, the extent of disease was defined and disease behaviour characterized. Over 80% of patients had concomitant colonic and/or gastroduodenal involvement with Crohn's disease, suggesting that this entity may represent a specific clinical phenotype of extensive disease localization. Classification of Crohn's disease behaviour using the Vienna classification schema revealed that virtually all patients in this study suffered from intestinal stricture formation or penetrating disease complications. Moreover, pharmacological therapies with corticosteroids and immunosuppressant drugs were rarely successful, with virtually all patients requiring at least one, and usually multiple, intestinal resections. Finally, most patients required long-term nutritional support, often with home parenteral nutrition. New treatments are required, possibly defined on the basis of their effectiveness in reducing the severity and extent of intestinal disease, rather than more conventional statistically driven reductions in disease activity indexes. |
| format | Article |
| id | doaj-art-ebe4ac2b6983461181e375b2c0c05952 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-ebe4ac2b6983461181e375b2c0c059522025-02-03T01:23:16ZengWileyCanadian Journal of Gastroenterology0835-79002005-01-0119957557810.1155/2005/647459Long-Term Clinical Behavior of Jejunoileal Involvement in Crohn’s DiseaseHugh J Freeman0Department of Medicine (Gastroenterology), , ,, University of British Columbia, University of British Columbia, Vancouver, British Columbia, CanadaDiffuse and extensive jejunoileal Crohn's disease is an uncommon entity. In 39 patients, including 21 males and 18 females, followed for a mean duration of over 16 years between 1979 and 2004, the extent of disease was defined and disease behaviour characterized. Over 80% of patients had concomitant colonic and/or gastroduodenal involvement with Crohn's disease, suggesting that this entity may represent a specific clinical phenotype of extensive disease localization. Classification of Crohn's disease behaviour using the Vienna classification schema revealed that virtually all patients in this study suffered from intestinal stricture formation or penetrating disease complications. Moreover, pharmacological therapies with corticosteroids and immunosuppressant drugs were rarely successful, with virtually all patients requiring at least one, and usually multiple, intestinal resections. Finally, most patients required long-term nutritional support, often with home parenteral nutrition. New treatments are required, possibly defined on the basis of their effectiveness in reducing the severity and extent of intestinal disease, rather than more conventional statistically driven reductions in disease activity indexes.http://dx.doi.org/10.1155/2005/647459 |
| spellingShingle | Hugh J Freeman Long-Term Clinical Behavior of Jejunoileal Involvement in Crohn’s Disease Canadian Journal of Gastroenterology |
| title | Long-Term Clinical Behavior of Jejunoileal Involvement in Crohn’s Disease |
| title_full | Long-Term Clinical Behavior of Jejunoileal Involvement in Crohn’s Disease |
| title_fullStr | Long-Term Clinical Behavior of Jejunoileal Involvement in Crohn’s Disease |
| title_full_unstemmed | Long-Term Clinical Behavior of Jejunoileal Involvement in Crohn’s Disease |
| title_short | Long-Term Clinical Behavior of Jejunoileal Involvement in Crohn’s Disease |
| title_sort | long term clinical behavior of jejunoileal involvement in crohn s disease |
| url | http://dx.doi.org/10.1155/2005/647459 |
| work_keys_str_mv | AT hughjfreeman longtermclinicalbehaviorofjejunoilealinvolvementincrohnsdisease |