Spontaneous Coronary Artery Dissection and a Family History of Aortic Dissection: A Genetic Association Study

Spontaneous Coronary Artery Dissection and a Family History of Aortic Dissection: A Genetic Association Study

Background Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndrome or sudden cardiac death, primarily affecting relatively young women (median age, 51 years) without typical cardiovascular risk factors. SCAD has a genetic component, with genome‐wi...

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Main Authors: Lucy McGrath‐Cadell, Stephanie Hesselson, Ingrid Tarr, Emma M. Rath, Michael Troup, Yunkai Gao, Keerat Junday, Monique Bax, Siiri E. Iismaa, Nicholas Collins, David W. M. Muller, Jason C. Kovacic, Eleni Giannoulatou, Robert M. Graham
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
spontaneous coronary artery dissection
aortic dissection
whole genome sequencing
pathogenic variants
polygenic risk score
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.037921
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