The neural mechanism and pathways underlying postoperative nausea and vomiting: a comprehensive review
Abstract This scoping review aims to synthesize evidence regarding the neural mechanisms and pathways underlying postoperative nausea and vomiting (PONV). We systematically searched the PubMed, Embase and Cochrane Library databases up to 2024. The findings indicate that PONV is a common complication...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-025-02632-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849728348650995712 |
|---|---|
| author | Zhu Zhang Xin Wang |
| author_facet | Zhu Zhang Xin Wang |
| author_sort | Zhu Zhang |
| collection | DOAJ |
| description | Abstract This scoping review aims to synthesize evidence regarding the neural mechanisms and pathways underlying postoperative nausea and vomiting (PONV). We systematically searched the PubMed, Embase and Cochrane Library databases up to 2024. The findings indicate that PONV is a common complications after surgeries involving anaesthesia and can also lead to severe postoperative discomfort. Various surgical procedures and anaesthesia methods can trigger PONV, and the underlying neural mechanisms and signalling pathways are complex. It is currently assumed that these pathways do not exist independently of each other but that a central mode generator encompasses all relevant neurons and conducting nerve fibres, including the nucleus of the solitary tract, the dorsal nucleus of the tenth nerve, the area of the nerve, etc. After the information is integrated, it is transferred to the digestive tract, thereby causing PONV. In this article, we discuss the progress of research on the factors that influence PONV and identify the underlying pathways. |
| format | Article |
| id | doaj-art-ebda9a1e881946f68e36ec734bb29c40 |
| institution | DOAJ |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-ebda9a1e881946f68e36ec734bb29c402025-08-20T03:09:34ZengBMCEuropean Journal of Medical Research2047-783X2025-05-013011810.1186/s40001-025-02632-1The neural mechanism and pathways underlying postoperative nausea and vomiting: a comprehensive reviewZhu Zhang0Xin Wang1The First Clinical Institute, Zunyi Medical UniversityThe First Clinical Institute, Zunyi Medical UniversityAbstract This scoping review aims to synthesize evidence regarding the neural mechanisms and pathways underlying postoperative nausea and vomiting (PONV). We systematically searched the PubMed, Embase and Cochrane Library databases up to 2024. The findings indicate that PONV is a common complications after surgeries involving anaesthesia and can also lead to severe postoperative discomfort. Various surgical procedures and anaesthesia methods can trigger PONV, and the underlying neural mechanisms and signalling pathways are complex. It is currently assumed that these pathways do not exist independently of each other but that a central mode generator encompasses all relevant neurons and conducting nerve fibres, including the nucleus of the solitary tract, the dorsal nucleus of the tenth nerve, the area of the nerve, etc. After the information is integrated, it is transferred to the digestive tract, thereby causing PONV. In this article, we discuss the progress of research on the factors that influence PONV and identify the underlying pathways.https://doi.org/10.1186/s40001-025-02632-1AnaesthesiaPostoperative nausea and vomitingInducementNeural pathways |
| spellingShingle | Zhu Zhang Xin Wang The neural mechanism and pathways underlying postoperative nausea and vomiting: a comprehensive review European Journal of Medical Research Anaesthesia Postoperative nausea and vomiting Inducement Neural pathways |
| title | The neural mechanism and pathways underlying postoperative nausea and vomiting: a comprehensive review |
| title_full | The neural mechanism and pathways underlying postoperative nausea and vomiting: a comprehensive review |
| title_fullStr | The neural mechanism and pathways underlying postoperative nausea and vomiting: a comprehensive review |
| title_full_unstemmed | The neural mechanism and pathways underlying postoperative nausea and vomiting: a comprehensive review |
| title_short | The neural mechanism and pathways underlying postoperative nausea and vomiting: a comprehensive review |
| title_sort | neural mechanism and pathways underlying postoperative nausea and vomiting a comprehensive review |
| topic | Anaesthesia Postoperative nausea and vomiting Inducement Neural pathways |
| url | https://doi.org/10.1186/s40001-025-02632-1 |
| work_keys_str_mv | AT zhuzhang theneuralmechanismandpathwaysunderlyingpostoperativenauseaandvomitingacomprehensivereview AT xinwang theneuralmechanismandpathwaysunderlyingpostoperativenauseaandvomitingacomprehensivereview AT zhuzhang neuralmechanismandpathwaysunderlyingpostoperativenauseaandvomitingacomprehensivereview AT xinwang neuralmechanismandpathwaysunderlyingpostoperativenauseaandvomitingacomprehensivereview |