Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms
Abstract Background Systemic lupus erythematosus (SLE) often presents with neuropsychiatric (NP) involvement, including cognitive impairment and depression. Past magnetic resonance imaging (MRI) research in SLE patients showed smaller hippocampal volumes but did not investigate other medial temporal...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s41927-024-00448-w |
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| author | Z. Makdad Najeeb P. C. Sundgren A. Jönsen K. Zervides J. Lätt T. Salomonsson J. Nystedt P. Nilsson A. Bengtsson G. Kuchcinski L. E. M. Wisse |
| author_facet | Z. Makdad Najeeb P. C. Sundgren A. Jönsen K. Zervides J. Lätt T. Salomonsson J. Nystedt P. Nilsson A. Bengtsson G. Kuchcinski L. E. M. Wisse |
| author_sort | Z. Makdad Najeeb |
| collection | DOAJ |
| description | Abstract Background Systemic lupus erythematosus (SLE) often presents with neuropsychiatric (NP) involvement, including cognitive impairment and depression. Past magnetic resonance imaging (MRI) research in SLE patients showed smaller hippocampal volumes but did not investigate other medial temporal lobe (MTL) regions. Our study aims to compare MTL subregional volumes in SLE patients to healthy individuals (HI) and explore MTL subregional volumes in relation to neuropsychiatric SLE (NPSLE) manifestations. Methods A total of 70 SLE patients and 25 HI underwent clinical evaluation, cognitive testing, and 3 tesla MRI imaging. T1-weighted MRI images were analyzed using the Automatic Segmentation of Hippocampal Subfields-T1 software. Analyses of Covariance were used to compare MTL subregion volumes between SLE and HI, and between NPSLE and non-NPSLE patients according to three models: the American College of Rheumatology (ACR) model defined by the ACR case definitions for NPSLE (n = 42), the more stringent Systemic Lupus International Collaborating Clinics (SLICC) B model (n = 21), and the most stringent SLICC A model (n = 15). Additionally, we explored the relation between MTL subregion volumes, cognitive functions, and depression scores in SLE patients using partial correlation analyses. Results Significantly smaller volumes of bilateral whole hippocampus, anterior hippocampus, posterior hippocampus, and Brodmann Area 35 were demonstrated in NPSLE compared to non-NPSLE patients according to the ACR model (p = 0.01, p = 0.03, p = 0.04, and p = 0.01 respectively). The differences did not reach significance according to the SLICC B and SLICC A models. No significant differences in MTL subregional volumes between SLE patients and HI were found. Partial correlation analyses showed a significant positive correlation between left Brodmann Area 35 volume and complex attention scores in SLE patients. No significant associations between MTL subregion volumes and depression scores were demonstrated. Conclusions NPSLE patients display significantly smaller volumes in various subregions of the MTL compared to non-NPSLE patients. These findings are suggestive of neuronal damage in MTL subregions in NPSLE patients on a group level. |
| format | Article |
| id | doaj-art-ebcebf376c0a423fb9a2ab5d5e9f7c25 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-ebcebf376c0a423fb9a2ab5d5e9f7c252025-01-26T12:57:30ZengBMCBMC Rheumatology2520-10262025-01-019111110.1186/s41927-024-00448-wAltered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptomsZ. Makdad Najeeb0P. C. Sundgren1A. Jönsen2K. Zervides3J. Lätt4T. Salomonsson5J. Nystedt6P. Nilsson7A. Bengtsson8G. Kuchcinski9L. E. M. Wisse10Department of Clinical Sciences, Diagnostic Radiology, Lund, Lund UniversityDepartment of Clinical Sciences, Diagnostic Radiology, Lund, Lund UniversityDepartment of Clinical Sciences Lund, Rheumatology, Lund University, Skåne University HospitalDepartment of Clinical Sciences Lund, Rheumatology, Lund University, Skåne University HospitalDepartment of Medical Imaging and Physiology, Skåne University hospitalDepartment of Clinical Sciences, Diagnostic Radiology, Lund, Lund UniversityDepartment of Clinical Sciences, Diagnostic Radiology, Lund, Lund UniversityDepartment of Clinical Sciences Lund, Neurology, Lund University, Skåne University HospitalDepartment of Clinical Sciences Lund, Rheumatology, Lund University, Skåne University HospitalUniversity Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & CognitionDepartment of Clinical Sciences, Diagnostic Radiology, Lund, Lund UniversityAbstract Background Systemic lupus erythematosus (SLE) often presents with neuropsychiatric (NP) involvement, including cognitive impairment and depression. Past magnetic resonance imaging (MRI) research in SLE patients showed smaller hippocampal volumes but did not investigate other medial temporal lobe (MTL) regions. Our study aims to compare MTL subregional volumes in SLE patients to healthy individuals (HI) and explore MTL subregional volumes in relation to neuropsychiatric SLE (NPSLE) manifestations. Methods A total of 70 SLE patients and 25 HI underwent clinical evaluation, cognitive testing, and 3 tesla MRI imaging. T1-weighted MRI images were analyzed using the Automatic Segmentation of Hippocampal Subfields-T1 software. Analyses of Covariance were used to compare MTL subregion volumes between SLE and HI, and between NPSLE and non-NPSLE patients according to three models: the American College of Rheumatology (ACR) model defined by the ACR case definitions for NPSLE (n = 42), the more stringent Systemic Lupus International Collaborating Clinics (SLICC) B model (n = 21), and the most stringent SLICC A model (n = 15). Additionally, we explored the relation between MTL subregion volumes, cognitive functions, and depression scores in SLE patients using partial correlation analyses. Results Significantly smaller volumes of bilateral whole hippocampus, anterior hippocampus, posterior hippocampus, and Brodmann Area 35 were demonstrated in NPSLE compared to non-NPSLE patients according to the ACR model (p = 0.01, p = 0.03, p = 0.04, and p = 0.01 respectively). The differences did not reach significance according to the SLICC B and SLICC A models. No significant differences in MTL subregional volumes between SLE patients and HI were found. Partial correlation analyses showed a significant positive correlation between left Brodmann Area 35 volume and complex attention scores in SLE patients. No significant associations between MTL subregion volumes and depression scores were demonstrated. Conclusions NPSLE patients display significantly smaller volumes in various subregions of the MTL compared to non-NPSLE patients. These findings are suggestive of neuronal damage in MTL subregions in NPSLE patients on a group level.https://doi.org/10.1186/s41927-024-00448-wSystemic lupus erythematosusNeuropsychiatric lupus erythematosusMedial temporal lobeHippocampusBrodmann Area 35Entorhinal cortex |
| spellingShingle | Z. Makdad Najeeb P. C. Sundgren A. Jönsen K. Zervides J. Lätt T. Salomonsson J. Nystedt P. Nilsson A. Bengtsson G. Kuchcinski L. E. M. Wisse Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms BMC Rheumatology Systemic lupus erythematosus Neuropsychiatric lupus erythematosus Medial temporal lobe Hippocampus Brodmann Area 35 Entorhinal cortex |
| title | Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms |
| title_full | Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms |
| title_fullStr | Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms |
| title_full_unstemmed | Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms |
| title_short | Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms |
| title_sort | altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms |
| topic | Systemic lupus erythematosus Neuropsychiatric lupus erythematosus Medial temporal lobe Hippocampus Brodmann Area 35 Entorhinal cortex |
| url | https://doi.org/10.1186/s41927-024-00448-w |
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