Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature
We present the case of an 82-year-old woman diagnosed with monoclonal gammopathy of renal significance (MGRS) with the presence of different and peculiar kidney lesions, who began treatment with bortezomib and dexamethasone, presenting during her evolution a relapse. Although the bone marrow biopsy...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2020/6679857 |
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| author | José C. De La Flor Marina Alonso Edna Sandoval Alexander Marschall Miguel Rodeles |
| author_facet | José C. De La Flor Marina Alonso Edna Sandoval Alexander Marschall Miguel Rodeles |
| author_sort | José C. De La Flor |
| collection | DOAJ |
| description | We present the case of an 82-year-old woman diagnosed with monoclonal gammopathy of renal significance (MGRS) with the presence of different and peculiar kidney lesions, who began treatment with bortezomib and dexamethasone, presenting during her evolution a relapse. Although the bone marrow biopsy in this case showed plasma cells as pathologic clone and there was also a reduction after chemotherapeutic treatment, rituximab was proposed as a second line. We suspected that the relapse was possibly due to another precursor as B-cell or lymphoplasmacytic cell clone. We review the literature and suggest that the treatment for MGRS should be patient-tailored, preferably by consulting a multidisciplinary team. Future research is needed to better understand the disease course and establish the efficacy and safety of the therapeutic approach for the relapse of MGRS. |
| format | Article |
| id | doaj-art-ebbe59a4e4cd42da9bc9b97aed092492 |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-ebbe59a4e4cd42da9bc9b97aed0924922025-02-03T01:28:30ZengWileyCase Reports in Nephrology2090-66412090-665X2020-01-01202010.1155/2020/66798576679857Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the LiteratureJosé C. De La Flor0Marina Alonso1Edna Sandoval2Alexander Marschall3Miguel Rodeles4Department of Nephrology, Hospital Central Defense Gomez Ulla, Madrid, SpainDepartment of Anatomic Pathology, Hospital 12 de Octubre, Madrid, SpainDepartment of Hematology, Hospital Central Defense Gomez Ulla, Madrid, SpainDepartment of Cardiology, Hospital Central Defense Gomez Ulla, Madrid, SpainDepartment of Nephrology, Hospital Central Defense Gomez Ulla, Madrid, SpainWe present the case of an 82-year-old woman diagnosed with monoclonal gammopathy of renal significance (MGRS) with the presence of different and peculiar kidney lesions, who began treatment with bortezomib and dexamethasone, presenting during her evolution a relapse. Although the bone marrow biopsy in this case showed plasma cells as pathologic clone and there was also a reduction after chemotherapeutic treatment, rituximab was proposed as a second line. We suspected that the relapse was possibly due to another precursor as B-cell or lymphoplasmacytic cell clone. We review the literature and suggest that the treatment for MGRS should be patient-tailored, preferably by consulting a multidisciplinary team. Future research is needed to better understand the disease course and establish the efficacy and safety of the therapeutic approach for the relapse of MGRS.http://dx.doi.org/10.1155/2020/6679857 |
| spellingShingle | José C. De La Flor Marina Alonso Edna Sandoval Alexander Marschall Miguel Rodeles Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature Case Reports in Nephrology |
| title | Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature |
| title_full | Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature |
| title_fullStr | Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature |
| title_full_unstemmed | Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature |
| title_short | Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature |
| title_sort | monoclonal gammopathy of renal significance with deposits of peculiar morphology and injuries of secondary thrombotic microangiopathy a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2020/6679857 |
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