Cognitive Pragmatic Rehabilitation Program in Schizophrenia: A Single Case fMRI Study
Introduction. The present study was intended to evaluate the effects of a rehabilitative training, the Cognitive Pragmatic Treatment (CPT), aimed at improving communicative-pragmatic abilities and the related cognitive components, on the cerebral modifications of a single case patient diagnosed with...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/1612078 |
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| author | Ilaria Gabbatore Francesca M. Bosco Elisabetta Geda Luigi Gastaldo Sergio Duca Tommaso Costa Bruno G. Bara Katiuscia Sacco |
| author_facet | Ilaria Gabbatore Francesca M. Bosco Elisabetta Geda Luigi Gastaldo Sergio Duca Tommaso Costa Bruno G. Bara Katiuscia Sacco |
| author_sort | Ilaria Gabbatore |
| collection | DOAJ |
| description | Introduction. The present study was intended to evaluate the effects of a rehabilitative training, the Cognitive Pragmatic Treatment (CPT), aimed at improving communicative-pragmatic abilities and the related cognitive components, on the cerebral modifications of a single case patient diagnosed with schizophrenia. Methods. The patient underwent two functional magnetic resonance imaging (fMRI) sessions, before and after the treatment. In order to assess brain changes, we calculated the Amplitude of Low Frequency Fluctuation (ALFF) index of the resting-state fMRI signal, which is interpreted as reflecting the intensity of the spontaneous regional activity of the brain. Behavioural measures of the patient’s communicative performance were also gathered before and after training and at follow-up. Results. The patient improved his communicative performance in almost all tests. Posttraining stronger ALFF signal emerged in the superior, inferior, and medial frontal gyri, as well as the superior temporal gyri. Conclusions. Even if based on a single case study, these preliminary results show functional changes at the cerebral level that seem to support the patient’s behavioural improvements. |
| format | Article |
| id | doaj-art-ebb01cced85844ff9e5b0505e7bec48e |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-ebb01cced85844ff9e5b0505e7bec48e2025-02-03T01:33:03ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/16120781612078Cognitive Pragmatic Rehabilitation Program in Schizophrenia: A Single Case fMRI StudyIlaria Gabbatore0Francesca M. Bosco1Elisabetta Geda2Luigi Gastaldo3Sergio Duca4Tommaso Costa5Bruno G. Bara6Katiuscia Sacco7Faculty of Humanities, Research Unit of Logopedics, Child Language Research Center, University of Oulu, Oulu, FinlandCenter for Cognitive Science (CSC), University and Polytechnic of Turin, Turin, ItalyBrain Imaging Group (BIG), Koelliker Hospital, Turin, ItalyPsychiatric Service, Mental Health Department, ASL-TO3, Turin, ItalyCCS fMRI, Koelliker Hospital, Turin, ItalyDepartment of Psychology, University of Turin, Turin, ItalyCenter for Cognitive Science (CSC), University and Polytechnic of Turin, Turin, ItalyDepartment of Psychology, University of Turin, Turin, ItalyIntroduction. The present study was intended to evaluate the effects of a rehabilitative training, the Cognitive Pragmatic Treatment (CPT), aimed at improving communicative-pragmatic abilities and the related cognitive components, on the cerebral modifications of a single case patient diagnosed with schizophrenia. Methods. The patient underwent two functional magnetic resonance imaging (fMRI) sessions, before and after the treatment. In order to assess brain changes, we calculated the Amplitude of Low Frequency Fluctuation (ALFF) index of the resting-state fMRI signal, which is interpreted as reflecting the intensity of the spontaneous regional activity of the brain. Behavioural measures of the patient’s communicative performance were also gathered before and after training and at follow-up. Results. The patient improved his communicative performance in almost all tests. Posttraining stronger ALFF signal emerged in the superior, inferior, and medial frontal gyri, as well as the superior temporal gyri. Conclusions. Even if based on a single case study, these preliminary results show functional changes at the cerebral level that seem to support the patient’s behavioural improvements.http://dx.doi.org/10.1155/2017/1612078 |
| spellingShingle | Ilaria Gabbatore Francesca M. Bosco Elisabetta Geda Luigi Gastaldo Sergio Duca Tommaso Costa Bruno G. Bara Katiuscia Sacco Cognitive Pragmatic Rehabilitation Program in Schizophrenia: A Single Case fMRI Study Neural Plasticity |
| title | Cognitive Pragmatic Rehabilitation Program in Schizophrenia: A Single Case fMRI Study |
| title_full | Cognitive Pragmatic Rehabilitation Program in Schizophrenia: A Single Case fMRI Study |
| title_fullStr | Cognitive Pragmatic Rehabilitation Program in Schizophrenia: A Single Case fMRI Study |
| title_full_unstemmed | Cognitive Pragmatic Rehabilitation Program in Schizophrenia: A Single Case fMRI Study |
| title_short | Cognitive Pragmatic Rehabilitation Program in Schizophrenia: A Single Case fMRI Study |
| title_sort | cognitive pragmatic rehabilitation program in schizophrenia a single case fmri study |
| url | http://dx.doi.org/10.1155/2017/1612078 |
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