Bismuth doped carbon nanospheres conjugated to boronated porphyrins for photodynamic therapy
Novel 4- (5,10,15)-tris-boronphenyl-20-(4-formylphenoxy) porphyrin (complex 1) and its Zn-metalated derivative (complex 2) were synthesized and conjugated to bismuth doped carbon nanospheres (BiCNS) through non-covalent bonds (π−π). The conjugation of BiCNS to porphyrin complexes enhanced the single...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025000961 |
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| author | N․Bridged Magaela Muthumuni Managa Tebello Nyokong |
| author_facet | N․Bridged Magaela Muthumuni Managa Tebello Nyokong |
| author_sort | N․Bridged Magaela |
| collection | DOAJ |
| description | Novel 4- (5,10,15)-tris-boronphenyl-20-(4-formylphenoxy) porphyrin (complex 1) and its Zn-metalated derivative (complex 2) were synthesized and conjugated to bismuth doped carbon nanospheres (BiCNS) through non-covalent bonds (π−π). The conjugation of BiCNS to porphyrin complexes enhanced the singlet oxygen production of porphyrin complexes, as it was observed that porphyrin complex 1 gave a singlet oxygen quantum yield (Φ∆) value of 0.17 and complex 2 gave Φ∆ of 0.23, and upon conjugation with BiCNS the Ф∆ values increased to 0.52 and 0.67, respectively. Photodynamic therapy (PDT) studies were performed against MDA-MB-231 breast cancer cell line using these complexes and their conjugates and it was observed that BiCNS conjugates resulted in enhanced PDT activity when compared to CNS conjugates. Conjugates 2-CNS, and 2-BiCNS at the concentration of 100 µg/mL they resulted with cell viabilities of 28.43 and 26.82 %, respectively. |
| format | Article |
| id | doaj-art-eba0e6077f014793bbf78ee4cf84798e |
| institution | DOAJ |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-eba0e6077f014793bbf78ee4cf84798e2025-08-20T03:08:24ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-06-015310456710.1016/j.pdpdt.2025.104567Bismuth doped carbon nanospheres conjugated to boronated porphyrins for photodynamic therapyN․Bridged Magaela0Muthumuni Managa1Tebello Nyokong2Institute for Nanotechnology Innovation, Rhodes University, Makhanda 6140, South AfricaInstitute for Nanotechnology and Water Sustainability (iNanoWS), Florida Campus, College of Science, Engineering and Technology, University of South Africa, Johannesburg 1710, South AfricaInstitute for Nanotechnology Innovation, Rhodes University, Makhanda 6140, South Africa; Corresponding author.Novel 4- (5,10,15)-tris-boronphenyl-20-(4-formylphenoxy) porphyrin (complex 1) and its Zn-metalated derivative (complex 2) were synthesized and conjugated to bismuth doped carbon nanospheres (BiCNS) through non-covalent bonds (π−π). The conjugation of BiCNS to porphyrin complexes enhanced the singlet oxygen production of porphyrin complexes, as it was observed that porphyrin complex 1 gave a singlet oxygen quantum yield (Φ∆) value of 0.17 and complex 2 gave Φ∆ of 0.23, and upon conjugation with BiCNS the Ф∆ values increased to 0.52 and 0.67, respectively. Photodynamic therapy (PDT) studies were performed against MDA-MB-231 breast cancer cell line using these complexes and their conjugates and it was observed that BiCNS conjugates resulted in enhanced PDT activity when compared to CNS conjugates. Conjugates 2-CNS, and 2-BiCNS at the concentration of 100 µg/mL they resulted with cell viabilities of 28.43 and 26.82 %, respectively.http://www.sciencedirect.com/science/article/pii/S1572100025000961Carbon nanospheresBismuthBoronated porphyrinPhotodynamic therapySinglet oxygenBreast cancer cell line |
| spellingShingle | N․Bridged Magaela Muthumuni Managa Tebello Nyokong Bismuth doped carbon nanospheres conjugated to boronated porphyrins for photodynamic therapy Photodiagnosis and Photodynamic Therapy Carbon nanospheres Bismuth Boronated porphyrin Photodynamic therapy Singlet oxygen Breast cancer cell line |
| title | Bismuth doped carbon nanospheres conjugated to boronated porphyrins for photodynamic therapy |
| title_full | Bismuth doped carbon nanospheres conjugated to boronated porphyrins for photodynamic therapy |
| title_fullStr | Bismuth doped carbon nanospheres conjugated to boronated porphyrins for photodynamic therapy |
| title_full_unstemmed | Bismuth doped carbon nanospheres conjugated to boronated porphyrins for photodynamic therapy |
| title_short | Bismuth doped carbon nanospheres conjugated to boronated porphyrins for photodynamic therapy |
| title_sort | bismuth doped carbon nanospheres conjugated to boronated porphyrins for photodynamic therapy |
| topic | Carbon nanospheres Bismuth Boronated porphyrin Photodynamic therapy Singlet oxygen Breast cancer cell line |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025000961 |
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