Application of in vitro and in vivo models in the study of food allergy
Food allergy is one of the most important food safety problems that has attracted increasing attention. The food allergy experimental models provide not only the accurate allergen detection and evaluation methods but also the powerful approaches for mechanism investigations. In this paper, we review...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2018-12-01
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| Series: | Food Science and Human Wellness |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453018300703 |
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| author | Jianjian Huang Changjun Liu Yanbo Wang Chong Wang Menghua Xie Yi Qian Linglin Fu |
| author_facet | Jianjian Huang Changjun Liu Yanbo Wang Chong Wang Menghua Xie Yi Qian Linglin Fu |
| author_sort | Jianjian Huang |
| collection | DOAJ |
| description | Food allergy is one of the most important food safety problems that has attracted increasing attention. The food allergy experimental models provide not only the accurate allergen detection and evaluation methods but also the powerful approaches for mechanism investigations. In this paper, we reviewed the common food allergy cell models including mast cell, basophil granulocyte and basophil, as well as the animal models of BALB/c mouse, C3H/HeJ mouse, and BN rat. We also introduced zebrafish, a promising model organism for investigating immunity though lacking direct applications in food allergy to date, and focused on traumatic inflammation, bacterial infection and viral infection models. In addition, we also summarized the clinical diagnostic research methods for food allergy. The elucidation of these topics will help researchers to understand the characteristics and mechanisms of various models and thus select the proper models for particular study, so as to support further investigations of food allergy. Keywords: Food allergy, Cell model, Animal model, Zebrafish, Clinical study |
| format | Article |
| id | doaj-art-eb9981f76d85485bba9f5093fff8085d |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2018-12-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-eb9981f76d85485bba9f5093fff8085d2025-02-03T06:34:59ZengTsinghua University PressFood Science and Human Wellness2213-45302018-12-0174235243Application of in vitro and in vivo models in the study of food allergyJianjian Huang0Changjun Liu1Yanbo Wang2Chong Wang3Menghua Xie4Yi Qian5Linglin Fu6School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, ChinaXiangshan County Aquatic Technology Promotion Station, Xiangshan, 315700, ChinaSchool of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China; Zhejiang Engineering Institute of Food Quality and Safety, Zhejiang Gongshang University, Hangzhou, ChinaSchool of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, ChinaSchool of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, ChinaSchool of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, ChinaSchool of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China; Zhejiang Engineering Institute of Food Quality and Safety, Zhejiang Gongshang University, Hangzhou, China; Corresponding author.Food allergy is one of the most important food safety problems that has attracted increasing attention. The food allergy experimental models provide not only the accurate allergen detection and evaluation methods but also the powerful approaches for mechanism investigations. In this paper, we reviewed the common food allergy cell models including mast cell, basophil granulocyte and basophil, as well as the animal models of BALB/c mouse, C3H/HeJ mouse, and BN rat. We also introduced zebrafish, a promising model organism for investigating immunity though lacking direct applications in food allergy to date, and focused on traumatic inflammation, bacterial infection and viral infection models. In addition, we also summarized the clinical diagnostic research methods for food allergy. The elucidation of these topics will help researchers to understand the characteristics and mechanisms of various models and thus select the proper models for particular study, so as to support further investigations of food allergy. Keywords: Food allergy, Cell model, Animal model, Zebrafish, Clinical studyhttp://www.sciencedirect.com/science/article/pii/S2213453018300703 |
| spellingShingle | Jianjian Huang Changjun Liu Yanbo Wang Chong Wang Menghua Xie Yi Qian Linglin Fu Application of in vitro and in vivo models in the study of food allergy Food Science and Human Wellness |
| title | Application of in vitro and in vivo models in the study of food allergy |
| title_full | Application of in vitro and in vivo models in the study of food allergy |
| title_fullStr | Application of in vitro and in vivo models in the study of food allergy |
| title_full_unstemmed | Application of in vitro and in vivo models in the study of food allergy |
| title_short | Application of in vitro and in vivo models in the study of food allergy |
| title_sort | application of in vitro and in vivo models in the study of food allergy |
| url | http://www.sciencedirect.com/science/article/pii/S2213453018300703 |
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