Integrative analysis of the expression profile and prognostic values of SENP gene family in hepatocellular carcinoma
Abstract Introduction Hepatocellular carcinoma (HCC) stands as the fourth leading cause of cancer-related deaths worldwide. SUMO-specific peptidases, known as SENPs, emerge as critical players, regulating tumorigenesis and progression of numerous cancer types. Despite this, the specific impact of SE...
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Springer
2025-05-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02598-w |
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| author | Xu Zhang Chenglei Zhao Tianyi Liu |
| author_facet | Xu Zhang Chenglei Zhao Tianyi Liu |
| author_sort | Xu Zhang |
| collection | DOAJ |
| description | Abstract Introduction Hepatocellular carcinoma (HCC) stands as the fourth leading cause of cancer-related deaths worldwide. SUMO-specific peptidases, known as SENPs, emerge as critical players, regulating tumorigenesis and progression of numerous cancer types. Despite this, the specific impact of SENPs in HCC remains unclear. Hence, our study aimed to reveal the immune and prognostic implications of SENPs in HCC. Methods The gene expression of SENP in various cancers was examined using open-access databases including TCGA, GTEx, and CPTAC. In order to investigate the prognostic potential of the SENP family, Kaplan–Meier analysis was used. To clarify the underlying biological mechanisms, gene set enrichment analysis (GSEA) was carried out. cBioPortal database was used to evaluate genetic mutation profiles. For insight into the relationship between SENP genes and tumor immunity, various algorithms were used. Results Our findings showed that SENP1, SENP2, SENP3, SENP5, SENP6, and SENP7 expression levels were significantly higher in HCC tumor tissues compared to normal tissues. In HCC patients, elevated SENP1 and SENP5 expression has been associated with tumor development and poor outcomes. Our immune infiltration patterns results also showed significant correlations between SENP5 expression and neutrophil (cor = 0.346, p < 0.001), myeloid dendritic cell (cor = 0.491, p < 0.001), macrophage (cor = 0.465, p < 0.001), and memory B cell (cor = 0.336, p < 0.001) infiltration in HCC, whereas SENP1 expression was associated with none of these infiltrations. Conclusions The prognostic and immunogenetic value of SENP1 and SENP5 in HCC was demonstrated in this study. Therefore, these two genes have the potential to function as separate prognostic biomarkers and offer promise as immunotherapeutic targets in the fight against HCC. |
| format | Article |
| id | doaj-art-eb982f16f73e415b8465f9a1bb8733e5 |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-eb982f16f73e415b8465f9a1bb8733e52025-08-20T01:51:36ZengSpringerDiscover Oncology2730-60112025-05-0116111610.1007/s12672-025-02598-wIntegrative analysis of the expression profile and prognostic values of SENP gene family in hepatocellular carcinomaXu Zhang0Chenglei Zhao1Tianyi Liu2Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical UniversityDepartment of Computed Tomography, The Second Affiliated Hospital of Harbin Medical UniversityDepartment of Pathology, The Second Affiliated Hospital of Harbin Medical UniversityAbstract Introduction Hepatocellular carcinoma (HCC) stands as the fourth leading cause of cancer-related deaths worldwide. SUMO-specific peptidases, known as SENPs, emerge as critical players, regulating tumorigenesis and progression of numerous cancer types. Despite this, the specific impact of SENPs in HCC remains unclear. Hence, our study aimed to reveal the immune and prognostic implications of SENPs in HCC. Methods The gene expression of SENP in various cancers was examined using open-access databases including TCGA, GTEx, and CPTAC. In order to investigate the prognostic potential of the SENP family, Kaplan–Meier analysis was used. To clarify the underlying biological mechanisms, gene set enrichment analysis (GSEA) was carried out. cBioPortal database was used to evaluate genetic mutation profiles. For insight into the relationship between SENP genes and tumor immunity, various algorithms were used. Results Our findings showed that SENP1, SENP2, SENP3, SENP5, SENP6, and SENP7 expression levels were significantly higher in HCC tumor tissues compared to normal tissues. In HCC patients, elevated SENP1 and SENP5 expression has been associated with tumor development and poor outcomes. Our immune infiltration patterns results also showed significant correlations between SENP5 expression and neutrophil (cor = 0.346, p < 0.001), myeloid dendritic cell (cor = 0.491, p < 0.001), macrophage (cor = 0.465, p < 0.001), and memory B cell (cor = 0.336, p < 0.001) infiltration in HCC, whereas SENP1 expression was associated with none of these infiltrations. Conclusions The prognostic and immunogenetic value of SENP1 and SENP5 in HCC was demonstrated in this study. Therefore, these two genes have the potential to function as separate prognostic biomarkers and offer promise as immunotherapeutic targets in the fight against HCC.https://doi.org/10.1007/s12672-025-02598-wHepatocellular carcinomaSENP familyBiomarkersPrognostic valueImmune infiltration |
| spellingShingle | Xu Zhang Chenglei Zhao Tianyi Liu Integrative analysis of the expression profile and prognostic values of SENP gene family in hepatocellular carcinoma Discover Oncology Hepatocellular carcinoma SENP family Biomarkers Prognostic value Immune infiltration |
| title | Integrative analysis of the expression profile and prognostic values of SENP gene family in hepatocellular carcinoma |
| title_full | Integrative analysis of the expression profile and prognostic values of SENP gene family in hepatocellular carcinoma |
| title_fullStr | Integrative analysis of the expression profile and prognostic values of SENP gene family in hepatocellular carcinoma |
| title_full_unstemmed | Integrative analysis of the expression profile and prognostic values of SENP gene family in hepatocellular carcinoma |
| title_short | Integrative analysis of the expression profile and prognostic values of SENP gene family in hepatocellular carcinoma |
| title_sort | integrative analysis of the expression profile and prognostic values of senp gene family in hepatocellular carcinoma |
| topic | Hepatocellular carcinoma SENP family Biomarkers Prognostic value Immune infiltration |
| url | https://doi.org/10.1007/s12672-025-02598-w |
| work_keys_str_mv | AT xuzhang integrativeanalysisoftheexpressionprofileandprognosticvaluesofsenpgenefamilyinhepatocellularcarcinoma AT chengleizhao integrativeanalysisoftheexpressionprofileandprognosticvaluesofsenpgenefamilyinhepatocellularcarcinoma AT tianyiliu integrativeanalysisoftheexpressionprofileandprognosticvaluesofsenpgenefamilyinhepatocellularcarcinoma |