Structural Analysis of Amylin and Amyloid β Peptide Signaling in Alzheimer’s Disease

Structural Analysis of Amylin and Amyloid β Peptide Signaling in Alzheimer’s Disease

Amylin and amyloid β belong to the same protein family and activate the same receptors. Amyloid β levels are elevated in Alzheimer’s disease. Recent studies have demonstrated that amylin-based peptides can reduce the symptoms of Alzheimer’s disease in animal models. Replica exchange molecular dynami...

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Bibliographic Details
Main Authors: Longsheng Xie, Christopher Lockhart, Steven R. Bowers, Dmitri K. Klimov, Mohsin Saleet Jafri
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomolecules
Subjects:
Alzheimer’s disease
amylin
amyloid β
molecular dynamics simulation
machine learning
Online Access:https://www.mdpi.com/2218-273X/15/1/89
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