Biomechanical Simulation of Peyronie’s Disease
A pathological disorder of human penile function, known as Peyronie’s disease, is characterized by the formation of plaque particles within the tunica albuginea. The plagues in the shape of rigid plate form in the scars as a result of the imperfect healing process. Due to high stiffness, plagues are...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Applied Bionics and Biomechanics |
| Online Access: | http://dx.doi.org/10.1155/2021/6669822 |
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| author | Pavel Drlík Vladimír Červenka Jan Červenka |
| author_facet | Pavel Drlík Vladimír Červenka Jan Červenka |
| author_sort | Pavel Drlík |
| collection | DOAJ |
| description | A pathological disorder of human penile function, known as Peyronie’s disease, is characterized by the formation of plaque particles within the tunica albuginea. The plagues in the shape of rigid plate form in the scars as a result of the imperfect healing process. Due to high stiffness, plagues are the source of pain and anomalous deformations during erectile penis function. The authors simulate the biomechanical behavior of the penile structure by a 3D finite element model. The numerical model is based on the real geometrical shape and the tissue structure with consideration of large nonlinear deformations. The penile erection is modeled by the initial strains imposed on the corpus cavernosa. The stress analysis is performed in a case study of various plague locations. The Peyronie’s syndrome manifested by the penis angular deviation simulated by the analysis is compared with the clinical data. The computational simulations provide a rational explanation for the clinical observations on patients. The objective is to apply the proposed modeling approach for the development and validation of treatment methods based on the application of shock waves. |
| format | Article |
| id | doaj-art-eb5378be6b2b4020abf56d19961476b1 |
| institution | Kabale University |
| issn | 1176-2322 1754-2103 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Applied Bionics and Biomechanics |
| spelling | doaj-art-eb5378be6b2b4020abf56d19961476b12025-02-03T05:51:12ZengWileyApplied Bionics and Biomechanics1176-23221754-21032021-01-01202110.1155/2021/66698226669822Biomechanical Simulation of Peyronie’s DiseasePavel Drlík0Vladimír Červenka1Jan Červenka2Central Military Hospital in Prague, Czech RepublicCervenka Consulting s.r.o., Prague, Czech RepublicCervenka Consulting s.r.o., Prague, Czech RepublicA pathological disorder of human penile function, known as Peyronie’s disease, is characterized by the formation of plaque particles within the tunica albuginea. The plagues in the shape of rigid plate form in the scars as a result of the imperfect healing process. Due to high stiffness, plagues are the source of pain and anomalous deformations during erectile penis function. The authors simulate the biomechanical behavior of the penile structure by a 3D finite element model. The numerical model is based on the real geometrical shape and the tissue structure with consideration of large nonlinear deformations. The penile erection is modeled by the initial strains imposed on the corpus cavernosa. The stress analysis is performed in a case study of various plague locations. The Peyronie’s syndrome manifested by the penis angular deviation simulated by the analysis is compared with the clinical data. The computational simulations provide a rational explanation for the clinical observations on patients. The objective is to apply the proposed modeling approach for the development and validation of treatment methods based on the application of shock waves.http://dx.doi.org/10.1155/2021/6669822 |
| spellingShingle | Pavel Drlík Vladimír Červenka Jan Červenka Biomechanical Simulation of Peyronie’s Disease Applied Bionics and Biomechanics |
| title | Biomechanical Simulation of Peyronie’s Disease |
| title_full | Biomechanical Simulation of Peyronie’s Disease |
| title_fullStr | Biomechanical Simulation of Peyronie’s Disease |
| title_full_unstemmed | Biomechanical Simulation of Peyronie’s Disease |
| title_short | Biomechanical Simulation of Peyronie’s Disease |
| title_sort | biomechanical simulation of peyronie s disease |
| url | http://dx.doi.org/10.1155/2021/6669822 |
| work_keys_str_mv | AT paveldrlik biomechanicalsimulationofpeyroniesdisease AT vladimircervenka biomechanicalsimulationofpeyroniesdisease AT jancervenka biomechanicalsimulationofpeyroniesdisease |