Joint association of systemic immune-inflammation index and phenotypic age acceleration with chronic respiratory disease: a cross-sectional study
Abstract Background Chronic respiratory diseases (CRD) represents a series of lung disorders and is posing a global health burden. Systemic inflammation and phenotypic ageing have been respectively reported to associate with certain CRD. However, little is known about the co-exposures and mutual ass...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-025-21430-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594377700016128 |
|---|---|
| author | Yuan Zhan Ruonan Yang Jie Feng Genlong Bai Xiangyun Shi Jiaheng Zhang Jingbo Zhang |
| author_facet | Yuan Zhan Ruonan Yang Jie Feng Genlong Bai Xiangyun Shi Jiaheng Zhang Jingbo Zhang |
| author_sort | Yuan Zhan |
| collection | DOAJ |
| description | Abstract Background Chronic respiratory diseases (CRD) represents a series of lung disorders and is posing a global health burden. Systemic inflammation and phenotypic ageing have been respectively reported to associate with certain CRD. However, little is known about the co-exposures and mutual associations of inflammation and ageing with CRD. Here, we aim to systematically elucidate the joint and mutual mediating associations of systemic immune-inflammation index (SII) and phenotypic age acceleration (PhenoAgeAccel) with CRD based on data from National Health and Nutrition Examination Survey (NHANES). Methods Data for this study was obtained from NHANES 2007–2010 and 2015–2018. The single and combined associations of SII and PhenoAgeAccel with CRD were analyzed using multivariable logistic regression models. The dose-response relationship between exposures and outcomes was determined by restricted cubic splines (RCS) regression. Subgroup and mediation analyses were further conducted. Results Totally, 15,075 participants were enrolled in this study including 3,587 CRD patients. Compare with controls, CRD patients tended to be older, females and present higher SII and PhenoAgeAccel values. Single-index analysis indicated that either SII or PhenoAgeAccel demonstrated a significantly positive association with CRD via logistic regressions and RCS curves. Furthermore, the joint-indexes analysis revealed that compared to individuals with lower SII and PhenoAgeAccel, those with higher SII and PhenoAgeAccel exhibited remarkably stronger associations with CRD (adjusted OR [aOR], 1.56; 95% CI, 1.31–1.85; P < 0.001), chronic obstructive pulmonary disease (aOR, 1.56; 95% CI, 1.22-2.00; P = 0.001) and asthma (aOR, 1.40; 95% CI, 1.16–1.70; P = 0.001), which were predominant among those aged above 40 years, females and smokers. Eventually, mediation analyses suggested the mutual mediating effects of SII and PhenoAgeAccel on CRD and PhenoAgeAccel mediated SII resulting in CRD more significantly. Conclusion This study confirmed the coexposure effect and mutual mediation between SII and PhenoAgeAccel on CRD. We recommend that the joint assessment may conduce to the accurate identification for populations susceptible to CRD and early prevention of chronic respiratory diseases. |
| format | Article |
| id | doaj-art-eb46f6ff32c64dd78cb4bdd0e4b6d0e7 |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-eb46f6ff32c64dd78cb4bdd0e4b6d0e72025-01-19T12:41:50ZengBMCBMC Public Health1471-24582025-01-0125111310.1186/s12889-025-21430-2Joint association of systemic immune-inflammation index and phenotypic age acceleration with chronic respiratory disease: a cross-sectional studyYuan Zhan0Ruonan Yang1Jie Feng2Genlong Bai3Xiangyun Shi4Jiaheng Zhang5Jingbo Zhang6Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Social Medicine and Health Management, School of Public Health, Huazhong University of Science and TechnologyDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical UniversityCollege of Geography and Resources, Sichuan Normal UniversityDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Background Chronic respiratory diseases (CRD) represents a series of lung disorders and is posing a global health burden. Systemic inflammation and phenotypic ageing have been respectively reported to associate with certain CRD. However, little is known about the co-exposures and mutual associations of inflammation and ageing with CRD. Here, we aim to systematically elucidate the joint and mutual mediating associations of systemic immune-inflammation index (SII) and phenotypic age acceleration (PhenoAgeAccel) with CRD based on data from National Health and Nutrition Examination Survey (NHANES). Methods Data for this study was obtained from NHANES 2007–2010 and 2015–2018. The single and combined associations of SII and PhenoAgeAccel with CRD were analyzed using multivariable logistic regression models. The dose-response relationship between exposures and outcomes was determined by restricted cubic splines (RCS) regression. Subgroup and mediation analyses were further conducted. Results Totally, 15,075 participants were enrolled in this study including 3,587 CRD patients. Compare with controls, CRD patients tended to be older, females and present higher SII and PhenoAgeAccel values. Single-index analysis indicated that either SII or PhenoAgeAccel demonstrated a significantly positive association with CRD via logistic regressions and RCS curves. Furthermore, the joint-indexes analysis revealed that compared to individuals with lower SII and PhenoAgeAccel, those with higher SII and PhenoAgeAccel exhibited remarkably stronger associations with CRD (adjusted OR [aOR], 1.56; 95% CI, 1.31–1.85; P < 0.001), chronic obstructive pulmonary disease (aOR, 1.56; 95% CI, 1.22-2.00; P = 0.001) and asthma (aOR, 1.40; 95% CI, 1.16–1.70; P = 0.001), which were predominant among those aged above 40 years, females and smokers. Eventually, mediation analyses suggested the mutual mediating effects of SII and PhenoAgeAccel on CRD and PhenoAgeAccel mediated SII resulting in CRD more significantly. Conclusion This study confirmed the coexposure effect and mutual mediation between SII and PhenoAgeAccel on CRD. We recommend that the joint assessment may conduce to the accurate identification for populations susceptible to CRD and early prevention of chronic respiratory diseases.https://doi.org/10.1186/s12889-025-21430-2Chronic respiratory diseasesSystemic immune-inflammation indexPhenotypic age accelerationCo-exposure effectMediation analysis |
| spellingShingle | Yuan Zhan Ruonan Yang Jie Feng Genlong Bai Xiangyun Shi Jiaheng Zhang Jingbo Zhang Joint association of systemic immune-inflammation index and phenotypic age acceleration with chronic respiratory disease: a cross-sectional study BMC Public Health Chronic respiratory diseases Systemic immune-inflammation index Phenotypic age acceleration Co-exposure effect Mediation analysis |
| title | Joint association of systemic immune-inflammation index and phenotypic age acceleration with chronic respiratory disease: a cross-sectional study |
| title_full | Joint association of systemic immune-inflammation index and phenotypic age acceleration with chronic respiratory disease: a cross-sectional study |
| title_fullStr | Joint association of systemic immune-inflammation index and phenotypic age acceleration with chronic respiratory disease: a cross-sectional study |
| title_full_unstemmed | Joint association of systemic immune-inflammation index and phenotypic age acceleration with chronic respiratory disease: a cross-sectional study |
| title_short | Joint association of systemic immune-inflammation index and phenotypic age acceleration with chronic respiratory disease: a cross-sectional study |
| title_sort | joint association of systemic immune inflammation index and phenotypic age acceleration with chronic respiratory disease a cross sectional study |
| topic | Chronic respiratory diseases Systemic immune-inflammation index Phenotypic age acceleration Co-exposure effect Mediation analysis |
| url | https://doi.org/10.1186/s12889-025-21430-2 |
| work_keys_str_mv | AT yuanzhan jointassociationofsystemicimmuneinflammationindexandphenotypicageaccelerationwithchronicrespiratorydiseaseacrosssectionalstudy AT ruonanyang jointassociationofsystemicimmuneinflammationindexandphenotypicageaccelerationwithchronicrespiratorydiseaseacrosssectionalstudy AT jiefeng jointassociationofsystemicimmuneinflammationindexandphenotypicageaccelerationwithchronicrespiratorydiseaseacrosssectionalstudy AT genlongbai jointassociationofsystemicimmuneinflammationindexandphenotypicageaccelerationwithchronicrespiratorydiseaseacrosssectionalstudy AT xiangyunshi jointassociationofsystemicimmuneinflammationindexandphenotypicageaccelerationwithchronicrespiratorydiseaseacrosssectionalstudy AT jiahengzhang jointassociationofsystemicimmuneinflammationindexandphenotypicageaccelerationwithchronicrespiratorydiseaseacrosssectionalstudy AT jingbozhang jointassociationofsystemicimmuneinflammationindexandphenotypicageaccelerationwithchronicrespiratorydiseaseacrosssectionalstudy |