Indigenous gut microbiota constitutively drive release of ciliary neurotrophic factor from mucosal enteric glia to maintain the homeostasis of enteric neural circuits

Indigenous gut microbiota constitutively drive release of ciliary neurotrophic factor from mucosal enteric glia to maintain the homeostasis of enteric neural circuits

It has recently become clear that the gut microbiota influence intestinal motility, intestinal barrier function, and mucosal immune function; therefore, the gut microbiota are deeply involved in the maintenance of intestinal homeostasis. The effects of the gut microbiota on the enteric nervous syste...

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Bibliographic Details
Main Authors: Ryo Kato, Takeshi Yamamoto, Hanako Ogata, Kana Miyata, Shusaku Hayashi, Michael D. Gershon, Makoto Kadowaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
enteric glia
enteric nervous system
ciliary neurotrophic factor (CNTF)
gut microbiota
TLR4 (toll-like receptor 4)
antibiotics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1372670/full
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