Clinical Value of Renal Function Markers Combined with Blood Lipid Levels during Late Pregnancy to Predict Preeclampsia: A Retrospective Case-Control Study
Background: Preeclampsia (PE) is a common complication of pregnancy and there is currently a lack of valuable diagnostic and predictive methods for it. This study aimed to explore the association between renal function markers, blood lipid levels in late pregnancy and PE, then ass...
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IMR Press
2025-01-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/52/1/10.31083/CEOG26863 |
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| author | Jindi Zhang Pei Wang Jie Liu |
| author_facet | Jindi Zhang Pei Wang Jie Liu |
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| description | Background: Preeclampsia (PE) is a common complication of pregnancy and there is currently a lack of valuable diagnostic and predictive methods for it. This study aimed to explore the association between renal function markers, blood lipid levels in late pregnancy and PE, then assess the combined predictive value for PE. Methods: This was a retrospective case-control study that selected 263 eligible patients in late pregnancy diagnosed with PE as the case group and 264 healthy parturients as the control group. All participants were hospitalized from January 2021 to December 2023. The levels of serum renal function [creatinine (Cr), uric acid (UA) and urea] and blood lipid [total cholesterol (TC), triglycerides (TG) and high-density lipoprotein (HDL)] were compared between two groups. Logistic regression analysis was used to explore the association between these indicators and PE. Then the receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of them for PE. p < 0.05 was considered statistically significant. Results: Univariate analysis showed that the PE group had significantly higher levels of TG, Cr, UA, and urea than the control group [3.56 (3.01–4.38) mmol/L vs. 2.98 (2.50–3.42) mmol/L, 54.00 (47.00–62.00) μmol/L vs. 46.00 (42.00–51.00) μmol/L, 367.00 (305.50–425.00) μmol/L vs. 278.00 (244.00–306.00) μmol/L, 3.50 (2.75–4.40) mmol/L vs. 2.90 (2.60–3.55) mmol/L respectively]. Multivariable analysis showed that the serum TG [adjusted odds ratio (AOR) = 1.827 (95% confidence interval (95% CI) = 1.277–2.615)], Cr [AOR = 1.066 (95% CI = 1.028–1.106)] and UA [AOR = 1.016 (95% CI = 1.011–1.022)] were risk factors for PE (p < 0.001). ROC curves revealed that areas under the curve (AUC) were 0.703 (95% CI = 0.658–0.747), 0.734 (95% CI = 0.691–0.777) and 0.822 (95% CI = 0.786–0.857) respectively. The AUC, sensitivity and specificity of the combination of TG, Cr and UA were 0.864 (95% CI = 0.833–0.896), 76.4%, and 84.8%. Conclusions: The increased levels of serum TG, Cr and UA imply greater possibility of PE, thus they are considered as the risk factors. And their combination has a certain predictive value for PE, which may offer a fresh, convenient and efficient method for the diagnosis and treatment of PE. |
| format | Article |
| id | doaj-art-eb4163a39d294b2aad0f1a032feff184 |
| institution | Kabale University |
| issn | 0390-6663 |
| language | English |
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| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-eb4163a39d294b2aad0f1a032feff1842025-01-25T07:14:26ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632025-01-015212686310.31083/CEOG26863S0390-6663(24)02528-4Clinical Value of Renal Function Markers Combined with Blood Lipid Levels during Late Pregnancy to Predict Preeclampsia: A Retrospective Case-Control StudyJindi Zhang0Pei Wang1Jie Liu2Department of Obstetrics, Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital), 310008 Hangzhou, Zhejiang, ChinaDepartment of Obstetrics, Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital), 310008 Hangzhou, Zhejiang, ChinaDepartment of Obstetrics, Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital), 310008 Hangzhou, Zhejiang, ChinaBackground: Preeclampsia (PE) is a common complication of pregnancy and there is currently a lack of valuable diagnostic and predictive methods for it. This study aimed to explore the association between renal function markers, blood lipid levels in late pregnancy and PE, then assess the combined predictive value for PE. Methods: This was a retrospective case-control study that selected 263 eligible patients in late pregnancy diagnosed with PE as the case group and 264 healthy parturients as the control group. All participants were hospitalized from January 2021 to December 2023. The levels of serum renal function [creatinine (Cr), uric acid (UA) and urea] and blood lipid [total cholesterol (TC), triglycerides (TG) and high-density lipoprotein (HDL)] were compared between two groups. Logistic regression analysis was used to explore the association between these indicators and PE. Then the receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of them for PE. p < 0.05 was considered statistically significant. Results: Univariate analysis showed that the PE group had significantly higher levels of TG, Cr, UA, and urea than the control group [3.56 (3.01–4.38) mmol/L vs. 2.98 (2.50–3.42) mmol/L, 54.00 (47.00–62.00) μmol/L vs. 46.00 (42.00–51.00) μmol/L, 367.00 (305.50–425.00) μmol/L vs. 278.00 (244.00–306.00) μmol/L, 3.50 (2.75–4.40) mmol/L vs. 2.90 (2.60–3.55) mmol/L respectively]. Multivariable analysis showed that the serum TG [adjusted odds ratio (AOR) = 1.827 (95% confidence interval (95% CI) = 1.277–2.615)], Cr [AOR = 1.066 (95% CI = 1.028–1.106)] and UA [AOR = 1.016 (95% CI = 1.011–1.022)] were risk factors for PE (p < 0.001). ROC curves revealed that areas under the curve (AUC) were 0.703 (95% CI = 0.658–0.747), 0.734 (95% CI = 0.691–0.777) and 0.822 (95% CI = 0.786–0.857) respectively. The AUC, sensitivity and specificity of the combination of TG, Cr and UA were 0.864 (95% CI = 0.833–0.896), 76.4%, and 84.8%. Conclusions: The increased levels of serum TG, Cr and UA imply greater possibility of PE, thus they are considered as the risk factors. And their combination has a certain predictive value for PE, which may offer a fresh, convenient and efficient method for the diagnosis and treatment of PE.https://www.imrpress.com/journal/CEOG/52/1/10.31083/CEOG26863blood lipidcreatinineuric acidtriglyceridespreeclampsiapredict |
| spellingShingle | Jindi Zhang Pei Wang Jie Liu Clinical Value of Renal Function Markers Combined with Blood Lipid Levels during Late Pregnancy to Predict Preeclampsia: A Retrospective Case-Control Study Clinical and Experimental Obstetrics & Gynecology blood lipid creatinine uric acid triglycerides preeclampsia predict |
| title | Clinical Value of Renal Function Markers Combined with Blood Lipid Levels during Late Pregnancy to Predict Preeclampsia: A Retrospective Case-Control Study |
| title_full | Clinical Value of Renal Function Markers Combined with Blood Lipid Levels during Late Pregnancy to Predict Preeclampsia: A Retrospective Case-Control Study |
| title_fullStr | Clinical Value of Renal Function Markers Combined with Blood Lipid Levels during Late Pregnancy to Predict Preeclampsia: A Retrospective Case-Control Study |
| title_full_unstemmed | Clinical Value of Renal Function Markers Combined with Blood Lipid Levels during Late Pregnancy to Predict Preeclampsia: A Retrospective Case-Control Study |
| title_short | Clinical Value of Renal Function Markers Combined with Blood Lipid Levels during Late Pregnancy to Predict Preeclampsia: A Retrospective Case-Control Study |
| title_sort | clinical value of renal function markers combined with blood lipid levels during late pregnancy to predict preeclampsia a retrospective case control study |
| topic | blood lipid creatinine uric acid triglycerides preeclampsia predict |
| url | https://www.imrpress.com/journal/CEOG/52/1/10.31083/CEOG26863 |
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