Monocyte‐predominant engraftment, cytokine levels and early transplant‐related complications in pediatric hematopoietic stem cell recipients
Abstract Myeloablative conditioning is a well‐established procedure that precedes hematopoietic stem cell transplantation (HSCT), particularly in pediatric patients. In the period directly following transplantation, several factors may contribute to complications that lead to the activation or damag...
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Wiley
2019-03-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.1912 |
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| author | Natalia Maximova Marilena Granzotto Francesca Barbieri Annalisa Marcuzzi Alberto Tommasini Lorenzo Monasta Roberto Simeone Davide Zanon Roberto Sala |
| author_facet | Natalia Maximova Marilena Granzotto Francesca Barbieri Annalisa Marcuzzi Alberto Tommasini Lorenzo Monasta Roberto Simeone Davide Zanon Roberto Sala |
| author_sort | Natalia Maximova |
| collection | DOAJ |
| description | Abstract Myeloablative conditioning is a well‐established procedure that precedes hematopoietic stem cell transplantation (HSCT), particularly in pediatric patients. In the period directly following transplantation, several factors may contribute to complications that lead to the activation or damage of endothelial cells, involved in the pathogenesis of vascular endothelial syndromes (VES). However, to date, sufficiently specific and sensitive diagnostic markers for the various forms of VES have not been identified. This was a retrospective single‐center study of patients who underwent allogeneic HSCT. For this cohort of patients, parameters including type of engraftment, donor characteristics, and cytokine production were measured and correlated with a high prevalence of short‐term complications after HSCT. The aim of this study was to identify specific parameters useful for improving diagnostics and predicting adverse effects in VES. We confirmed that monocyte‐predominant engraftment was related to a higher risk for an early transplant‐related complication termed sinusoidal obstruction syndrome (SOS). The increased production of specific cytokines, in particular RANTES, represents a marker associated with prevalent engraftment. In addition, patients undergoing prophylaxis with defibrotide had “classical” engraftment, a common cytokine profile and a lower incidence of life‐threatening transplant‐related complications. The beneficial effect of defibrotide might be a starting point for developing selective prophylaxis for patients with monocyte engraftment to prevent severe early transplant‐related complications. |
| format | Article |
| id | doaj-art-eb30361f9fd54aa09c611ac6e343a9e3 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-eb30361f9fd54aa09c611ac6e343a9e32025-01-31T08:47:42ZengWileyCancer Medicine2045-76342019-03-018389090110.1002/cam4.1912Monocyte‐predominant engraftment, cytokine levels and early transplant‐related complications in pediatric hematopoietic stem cell recipientsNatalia Maximova0Marilena Granzotto1Francesca Barbieri2Annalisa Marcuzzi3Alberto Tommasini4Lorenzo Monasta5Roberto Simeone6Davide Zanon7Roberto Sala8Institute for Maternal and Child Health—IRCCS “Burlo Garofolo” Trieste ItalyDepartment of Laboratory Medicine ASUITS Trieste ItalyDepartment of Medicine, Surgery and Health Sciences University of Trieste Trieste ItalyDepartment of Medicine, Surgery and Health Sciences University of Trieste Trieste ItalyInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo” Trieste ItalyInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo” Trieste ItalyDepartment of Laboratory Medicine ASUITS Trieste ItalyInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo” Trieste ItalyDepartment of Medicine and Surgery University of Parma Parma ItalyAbstract Myeloablative conditioning is a well‐established procedure that precedes hematopoietic stem cell transplantation (HSCT), particularly in pediatric patients. In the period directly following transplantation, several factors may contribute to complications that lead to the activation or damage of endothelial cells, involved in the pathogenesis of vascular endothelial syndromes (VES). However, to date, sufficiently specific and sensitive diagnostic markers for the various forms of VES have not been identified. This was a retrospective single‐center study of patients who underwent allogeneic HSCT. For this cohort of patients, parameters including type of engraftment, donor characteristics, and cytokine production were measured and correlated with a high prevalence of short‐term complications after HSCT. The aim of this study was to identify specific parameters useful for improving diagnostics and predicting adverse effects in VES. We confirmed that monocyte‐predominant engraftment was related to a higher risk for an early transplant‐related complication termed sinusoidal obstruction syndrome (SOS). The increased production of specific cytokines, in particular RANTES, represents a marker associated with prevalent engraftment. In addition, patients undergoing prophylaxis with defibrotide had “classical” engraftment, a common cytokine profile and a lower incidence of life‐threatening transplant‐related complications. The beneficial effect of defibrotide might be a starting point for developing selective prophylaxis for patients with monocyte engraftment to prevent severe early transplant‐related complications.https://doi.org/10.1002/cam4.1912cytokinesdefibrotidehematopoietic stem cell transplantationmonocyte‐predominant engraftmentpediatricshort‐term transplant‐related complication |
| spellingShingle | Natalia Maximova Marilena Granzotto Francesca Barbieri Annalisa Marcuzzi Alberto Tommasini Lorenzo Monasta Roberto Simeone Davide Zanon Roberto Sala Monocyte‐predominant engraftment, cytokine levels and early transplant‐related complications in pediatric hematopoietic stem cell recipients Cancer Medicine cytokines defibrotide hematopoietic stem cell transplantation monocyte‐predominant engraftment pediatric short‐term transplant‐related complication |
| title | Monocyte‐predominant engraftment, cytokine levels and early transplant‐related complications in pediatric hematopoietic stem cell recipients |
| title_full | Monocyte‐predominant engraftment, cytokine levels and early transplant‐related complications in pediatric hematopoietic stem cell recipients |
| title_fullStr | Monocyte‐predominant engraftment, cytokine levels and early transplant‐related complications in pediatric hematopoietic stem cell recipients |
| title_full_unstemmed | Monocyte‐predominant engraftment, cytokine levels and early transplant‐related complications in pediatric hematopoietic stem cell recipients |
| title_short | Monocyte‐predominant engraftment, cytokine levels and early transplant‐related complications in pediatric hematopoietic stem cell recipients |
| title_sort | monocyte predominant engraftment cytokine levels and early transplant related complications in pediatric hematopoietic stem cell recipients |
| topic | cytokines defibrotide hematopoietic stem cell transplantation monocyte‐predominant engraftment pediatric short‐term transplant‐related complication |
| url | https://doi.org/10.1002/cam4.1912 |
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