Chlorinated biscoumarins inhibit chikungunya virus replication in cell-based and animal models

Chlorinated biscoumarins inhibit chikungunya virus replication in cell-based and animal models

Biscoumarin derivatives were evaluated for antiviral activity against chikungunya virus (CHIKV), a re-emerging mosquito-borne alphavirus with no approved treatment. Compounds 3 and 4 demonstrated potent in vitro antiviral efficacy, with EC₅₀ values of 2.85 ± 0.42 µM and 3.08 ± 0.45 µM (SI > 20) f...

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Main Authors: Chidinma Nelson Orji, Naphat Loeanurit, Van-Can Pham, Thi-Hong-Truc Phan, Kowit Hengphasatporn, Yasuteru Shigeta, Altri Diana Putri, Laura Sandra Lello, Andres Merits, Noppadol Wacharachaisurapol, Wanna Eiamart, Supeecha Wittayalertpanya, Tanatorn Khotavivattana, Warinthorn Chavasiri, Siwaporn Boonyasuppayakorn
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Emerging Microbes and Infections
Subjects:
Biscoumarin
chikungunya virus
mice
efficacy
molecular docking
methyltransferase
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2025.2529889
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https://www.tandfonline.com/doi/10.1080/22221751.2025.2529889

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