Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is potentially lethal, but it is also a treatable autoimmune disorder characterized by prominent psychiatric and neurologic symptoms. It is often accompanied with teratoma or other neoplasm, especially in female patients. Anti-NMDAR antibodies...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/6361479 |
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| author | Cai-yun Liu Jie Zhu Xiang-Yu Zheng Chi Ma Xu Wang |
| author_facet | Cai-yun Liu Jie Zhu Xiang-Yu Zheng Chi Ma Xu Wang |
| author_sort | Cai-yun Liu |
| collection | DOAJ |
| description | Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is potentially lethal, but it is also a treatable autoimmune disorder characterized by prominent psychiatric and neurologic symptoms. It is often accompanied with teratoma or other neoplasm, especially in female patients. Anti-NMDAR antibodies in cerebrospinal fluid (CSF) and serum are characteristic features of the disease, thereby suggesting a pathogenic role in the disease. Here, we summarize recent studies that have clearly documented that both clinical manifestations and the antibodies may contribute to early diagnosis and multidisciplinary care. The clinical course of the disorder is reversible and the relapse could occur in some patients. Anti-NMDAR encephalitis coexisting with demyelinating disorders makes the diagnosis more complex; thus, clinicians should be aware of the overlapping diseases. |
| format | Article |
| id | doaj-art-eb2c9fba937b410282603a42b2e427c3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-eb2c9fba937b410282603a42b2e427c32025-02-03T01:29:07ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/63614796361479Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune EncephalitisCai-yun Liu0Jie Zhu1Xiang-Yu Zheng2Chi Ma3Xu Wang4Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Neurosurgery, The First Hospital of Jilin University, Jilin University, Changchun 130021, ChinaDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun 130021, ChinaAnti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is potentially lethal, but it is also a treatable autoimmune disorder characterized by prominent psychiatric and neurologic symptoms. It is often accompanied with teratoma or other neoplasm, especially in female patients. Anti-NMDAR antibodies in cerebrospinal fluid (CSF) and serum are characteristic features of the disease, thereby suggesting a pathogenic role in the disease. Here, we summarize recent studies that have clearly documented that both clinical manifestations and the antibodies may contribute to early diagnosis and multidisciplinary care. The clinical course of the disorder is reversible and the relapse could occur in some patients. Anti-NMDAR encephalitis coexisting with demyelinating disorders makes the diagnosis more complex; thus, clinicians should be aware of the overlapping diseases.http://dx.doi.org/10.1155/2017/6361479 |
| spellingShingle | Cai-yun Liu Jie Zhu Xiang-Yu Zheng Chi Ma Xu Wang Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis Mediators of Inflammation |
| title | Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis |
| title_full | Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis |
| title_fullStr | Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis |
| title_full_unstemmed | Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis |
| title_short | Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis |
| title_sort | anti n methyl d aspartate receptor encephalitis a severe potentially reversible autoimmune encephalitis |
| url | http://dx.doi.org/10.1155/2017/6361479 |
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