Gestational diabetes mellitus causes genome hyper-methylation of oocyte via increased EZH2

Gestational diabetes mellitus causes genome hyper-methylation of oocyte via increased EZH2

Abstract Gestational diabetes mellitus (GDM), a common pregnancy disease, has long-term negative effects on offspring health. Epigenetic changes may have important contributions to that, but the underlying mechanisms are not well understood. Here, we report the influence of GDM on DNA methylation of...

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Main Authors: Hong-Yan Guo, Shou-Bin Tang, Li-Jun Li, Jing Lin, Ting-Ting Zhang, Shuo Chao, Xiao-Wen Jin, Kui-Peng Xu, Xiao-Feng Su, Shen Yin, Ming-Hui Zhao, Gui-An Huang, Li-Jia Yang, Wei Shen, Lei Zhang, Cui-Lian Zhang, Qing-Yuan Sun, Zhao-Jia Ge
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55499-x
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